F-18 fluorodeoxyglucose
Updates to Article Attributes
Body
was changed:
F-18 fluorodeoxyglucose (FDG) is the most common PET radiotracer.
Structure
The radiopharmaceutical consists of the fluorine-18 radionuclide substituting the hydroxyl group at the C-2 position of glucose. The IUPAC chemical name is 2-deoxy-2-[18F]fluoroglucose.
Production
F-18 fluoride ion is created in a cyclotron and then converted via an automated chemistry module into F-18 FDG.
Pharmacokinetics
- physical half-life: 110 minutes
- excretion: renal
Biodistribution
Physiologic activity is commonly seen in the following organs:
- brain
- heart (especially left ventricular myocardium)
- kidneys and bladder (due to urinary excretion)
- liver (often used as an internal reference standard on whole body scans)
- gastrointestinal mucosa
Other sites of physiologic uptake are variable or less intense:
- skeletal muscle (in extremities after strenuous activity, in mouth and larynx after speech or chewing)
- brown fat (especially in the neck and mediastinum)
- hematopoietic/lymphoid tissue: Waldeyer ring, thymus, spleen, and bone marrow
- lactating breasts
Clinical uses
- brain
- identification of foci associated with epileptic seizures
- evaluation of suspected Alzheimer dementia
- whole body
- cancer staging and surveillance
- evaluation of patients with fever of unknown origin
- cardiac
- identification of viable and ischemic myocardium
See also
-<a title="Heart" href="/articles/heart">heart</a> (especially left ventricular myocardium)</li>- +<a href="/articles/heart">heart</a> (especially left ventricular myocardium)</li>
-<a title="Kidneys" href="/articles/kidneys">kidneys</a> and <a title="Bladder" href="/articles/urinary-bladder">bladder</a> (due to urinary excretion)</li>- +<a href="/articles/kidneys">kidneys</a> and <a href="/articles/urinary-bladder">bladder</a> (due to urinary excretion)</li>
-<a title="Liver" href="/articles/liver">liver</a> (often used as an internal reference standard on whole body scans)</li>- +<a href="/articles/liver">liver</a> (often used as an internal reference standard on whole body scans)</li>
-<a title="Gastrointestinal tract" href="/articles/gastrointestinal-tract">gastrointestinal</a> mucosa</li>- +<a href="/articles/gastrointestinal-tract">gastrointestinal</a> mucosa</li>
-<li>hematopoietic/lymphoid tissue: <a href="/articles/waldeyers-ring-1">Waldeyer ring</a>, <a href="/articles/thymus">thymus</a>, <a title="Spleen" href="/articles/spleen-1">spleen</a>, and <a href="/articles/bone-marrow">bone marrow</a>- +<li>hematopoietic/lymphoid tissue: <a href="/articles/waldeyers-ring-1">Waldeyer ring</a>, <a href="/articles/thymus">thymus</a>, <a href="/articles/spleen-1">spleen</a>, and <a href="/articles/bone-marrow">bone marrow</a>
-</ul>- +</ul><h4>See also</h4><p><a title="F-18 fluorodeoxyglucose (FDG) embolism" href="/articles/f-18-fluorodeoxyglucose-fdg-embolism">F-18 fluorodeoxyglucose (FDG) embolism</a></p>
Systems changed:
- Oncology
- Central Nervous System
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