F-18 fluorodeoxyglucose
Updates to Article Attributes
Body
was changed:
F-18 fluorodeoxyglucose (FDG) is the most common PET radiotracer.
Structure
The radiopharmaceutical consists of the fluorine-18 radionuclide substituting the hydroxyl group at the C-2 position of glucose. The IUPAC chemical name is 2-deoxy-2-[18F
Production
F-18 fluoride ion is created in a cyclotron and then converted via an automated chemistry module into F-18 FDG.
Pharmacokinetics
- physical half-life: 110 minutes
- excretion: renal
Biodistribution
Physiologic activity is commonly seen in the following organs:
- brain
- heart (especially left ventricular myocardium)
- kidneys and bladder (due to urinary excretion)
- liver (often used as an internal reference standard on whole body scans)
Other sites of physiologic uptake are variable or less intense:
- skeletal muscle (in extremities after strenuous activity, in mouth and larynx after speech or chewing)
- brown fat (especially in the neck and mediastinum)
- gastrointestinal mucosa
- hematopoietic/lymphoid tissue: Waldeyer ring, thymus, spleen, and bone marrow
- salivary glands
- lactating breasts
Clinical uses
- brain
- identification of foci associated with epileptic seizures
- evaluation of suspected Alzheimer dementia
- whole body
- cancer staging and surveillance
- evaluation of patients with fever of unknown origin
- cardiac
- identification of viable and ischemic myocardium
See also
-<p><strong>F-18 fluorodeoxyglucose </strong><strong>(FDG)</strong> is the most common <a href="/articles/pet-radiotracers">PET radiotracer</a>.</p><h4>Structure</h4><p>The radiopharmaceutical consists of the <a href="/articles/fluorine-18">fluorine-18</a> radionuclide substituting the hydroxyl group at the C-2 position of glucose. The <a href="/articles/iupac">IUPAC</a> chemical name is 2-deoxy-2-[<sup>18</sup>F]fluoroglucose.</p><h4>Production</h4><p>F-18 fluoride ion is created in a cyclotron and then converted via an automated chemistry module into F-18 FDG.</p><h4>Pharmacokinetics</h4><ul>- +<p><strong>F-18 fluorodeoxyglucose </strong><strong>(FDG)</strong> is the most common <a href="/articles/pet-radiotracers">PET radiotracer</a>.</p><h4>Structure</h4><p>The radiopharmaceutical consists of the <a href="/articles/fluorine-18">fluorine-18</a> radionuclide substituting the hydroxyl group at the C-2 position of glucose. The <a href="/articles/iupac">IUPAC</a> chemical name is 2-deoxy-2-[F-18]fluoroglucose.</p><h4>Production</h4><p>F-18 fluoride ion is created in a cyclotron and then converted via an automated chemistry module into F-18 FDG.</p><h4>Pharmacokinetics</h4><ul>
-<li>skeletal muscle (in extremities after strenuous activity, in mouth and larynx after speech or chewing)</li>- +<li>
- +<a title="Skeletal muscle" href="/articles/skeletal-muscle">skeletal muscle</a> (in extremities after strenuous activity, in mouth and larynx after speech or chewing)</li>
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