Pancreatic neoplasms
Updates to Article Attributes
Body
was changed:
There are numerous primary pancreatic neoplasms, in part due to the mixed endocrine and exocrine components.
Classification
Classification based on function
-
exocrine - ~ 99% of all primary pancreatic neoplasms
- pancreatic ductal adenocarcinoma ~ 90-95%
- cystic neoplasm
- intraductal papillary mucinous neoplasm (IPMN)
-
endocrine - were previously referred as islet cell tumors because they were thought to have originated from the islets of Langerhans. However, new evidence suggests that these tumors originate from pluripotential stem cells in ductal epithelium 6.
- non-functional
- functional
-
mesenchymal tumours
- although the great majority of both benign and malignant pancreatic neoplasms arise from pancreatic epithelial cells, mesenchymal tumors, while rare, can derive from the connective, lymphatic, vascular, and neuronal tissues of the pancreas7.
- they account for 1-2% of all pancreatic tumors and are classified according to their histologic origin7.
- other
Exocrine tumours
- ductal adenocarcinoma is by far the most common primary tumour, usually of the head (65%) and has a very poor prognosis.
-
cystic neoplasms are further divided into: (with some overlap)
- unilocular
- intraductal papillary mucinous neoplasms(IPMN)
- serous cystadenoma uncommonly uni/macro locular
- macrocystic - multilocular
- mucinous cystic neoplasm : usually body and tail
- intraductal papillary mucinous neoplasms (IPMN)
- serous cystadenoma uncommonly uni / macro locular
- microcystic
- serous cystadenoma - usually head. 30% have a central scar
- cystic with a solid component
- macrocystic tumours can have solid component also
- unilocular
- generally solid
See also - cystic pancreatic mass : differential diagnosis
Endocrine tumours
Endocrine tumours of the pancreas are divided into :
-
functional - ~ 85 %
- insulinoma - most common. 10% are malignant
- gastrinoma - second most common. 60% malignant
- glucagonoma - 80% malignant
- VIPoma - 75% malignant
- somatostatinoma - 75% malignant
-
non-functional - ~ 15% :
- third most common
- 85-100% malignant
- usually larger
Mesenchymal tumours
Account for 1-2% of all pancreatic tumors and are classified according to their histologic origin7:
- lymphangioma
- lipoma
- pancreatoblastoma
- teratoma
- lymphoma
- schwannoma
- neurofibroma
- sarcoma
Classification based on location
Head
- serous cystadenoma
- intraductal papillary mucinous neoplasms (IPMN)
- ductal adenocarcinoma
- pancreatoblastoma (rare and in children)
Body and tail
-<p>There are numerous primary <strong>pancreatic neoplasms</strong>, in part due to the mixed endocrine and exocrine components. </p><a name="Classification"></a><h4><span>Classification </span></h4><h5><span>Classification based on function</span></h5><ul>-<li>-<strong>exocrine </strong>- ~ 99% of all primary pancreatic neoplasms-<ul>-<li>-<a href="/articles/pancreatic-ductal-carcinoma">pancreatic ductal adenocarcinoma</a> ~ 90-95% </li>-<li>cystic neoplasm </li>-<li><a href="/articles/intraductal-papillary-mucinous-neoplasm" title="Intraductal papillary mucinous neoplasms (IPMN)">intraductal papillary mucinous neoplasm (IPMN) </a></li>-</ul>-</li>-<li>-<strong>endocrine </strong>- were previously referred as islet cell tumors because they were thought to have originated from the islets of Langerhans. However, new evidence suggests that these tumors originate from pluripotential stem cells in ductal epithelium <sup>6</sup>.-<ul>-<li>non-functional </li>-<li>functional </li>- +<p>There are numerous primary <strong>pancreatic neoplasms</strong>, in part due to the mixed endocrine and exocrine components.</p><p> </p><h4>Classification</h4><h5>Classification based on function</h5><ul>
- +<li>
- +<strong>exocrine </strong>- ~ 99% of all primary pancreatic neoplasms<ul>
- +<li>
- +<a href="/articles/pancreatic-ductal-carcinoma">pancreatic ductal adenocarcinoma</a> ~ 90-95%</li>
- +<li>cystic neoplasm</li>
- +<li><a href="/articles/intraductal-papillary-mucinous-neoplasm">intraductal papillary mucinous neoplasm (IPMN) </a></li>
- +</ul>
- +</li>
- +<li>
- +<strong>endocrine </strong>- were previously referred as islet cell tumors because they were thought to have originated from the islets of Langerhans. However, new evidence suggests that these tumors originate from pluripotential stem cells in ductal epithelium <sup>6</sup>.<ul>
- +<li>non-functional</li>
- +<li>functional</li>
-</li>-<li>- +</li>
- +<li>
-<li>although the great majority of both benign and malignant pancreatic neoplasms arise from pancreatic epithelial cells, mesenchymal tumors, while rare, can derive from the connective, lymphatic, vascular, and neuronal tissues of the pancreas<sup>7</sup>. </li>-<li>they account for 1-2% of all pancreatic tumors and are classified according to their histologic origin<sup>7</sup>. </li>- +<li>although the great majority of both benign and malignant pancreatic neoplasms arise from pancreatic epithelial cells, mesenchymal tumors, while rare, can derive from the connective, lymphatic, vascular, and neuronal tissues of the pancreas<sup>7</sup>. </li>
- +<li>they account for 1-2% of all pancreatic tumors and are classified according to their histologic origin<sup>7</sup>. </li>
-</li>-<li>-<strong>other</strong><ul><li><a href="/articles/pancreatic-metastases" title="Metastases to pancreas">metastases to pancreas</a></li></ul>-</li>-</ul><h5>Exocrine tumours</h5><a name="Exocrine_tumours"></a><ul>-<li>-<strong><span>ductal adenocarcinoma</span></strong> is by far the most common primary tumour, usually of the head (65%) and has a very poor prognosis. </li>-<li>-<strong>cystic neoplasms</strong> are further divided into: (with some overlap)-<ul>-<li>unilocular-<ul>-<li><a href="/articles/intraductal-papillary-mucinous-neoplasm" title="Intraductal papillary mucinous neoplasms (IPMN)">intraductal papillary mucinous neoplasms(IPMN)</a></li>-<li>-<a href="/articles/serous-cystadenoma-of-pancreas" title="Serous cystadenoma of pancreas">serous cystadenoma</a> uncommonly uni/macro locular </li>-</ul>-</li>-<li>macrocystic - multilocular-<ul>-<li>-<a href="/articles/mucinous-cystic-neoplasms-of-the-pancreas">mucinous cystic neoplasm</a> : usually body and tail </li>-<li><a href="/articles/intraductal-papillary-mucinous-neoplasm" title="Intraductal papillary mucinous neoplasms (IPMN)">intraductal papillary mucinous neoplasms (IPMN)</a></li>-<li>-<a href="/articles/serous-cystadenoma-of-pancreas" title="Serous cystadenoma of pancreas">serous cystadenoma</a> uncommonly uni / macro locular </li>-</ul>-</li>-<li>microcystic-<ul><li>-<a href="/articles/serous-cystadenoma-of-pancreas" title="Serous cystadenoma of pancreas">serous cystadenoma</a> - usually head. 30% have a central scar </li></ul>-</li>-<li>cystic with a solid component-<ul><li>macrocystic tumours can have solid component also</li></ul>-</li>-</ul>-</li>-<li>-<strong>generally solid </strong><ul><li><a href="/articles/solid-pseudopapillary-tumour-of-pancreas" title="solid-pseudopapillary tumour of pancreas">solid-pseudopapillary tumour of pancreas</a></li></ul>-</li>-</ul><p><strong>See also </strong>- <a href="/articles/cystic-lesions-of-the-pancreas">cystic pancreatic mass : differential diagnosis</a></p><h5>Endocrine tumours</h5><p><a href="/articles/endocrine-tumours-of-the-pancreas" title="Endocrine tumours of the pancreas">Endocrine tumours of the pancreas</a> are divided into :</p><ul>-<li>-<strong>functional</strong> - ~ 85 %-<ul>-<li>-<a href="/articles/insulinoma">insulinoma</a> - most common. 10% are malignant </li>-<li>-<a href="/articles/gastrinoma">gastrinoma</a> - second most common. 60% malignant </li>-<li>-<a href="/articles/glucagonoma">glucagonoma</a> - 80% malignant </li>-<li>-<a href="/articles/vipoma">VIPoma</a> - 75% malignant </li>-<li>-<a href="/articles/somatinoma">somatostatinoma</a> - 75% malignant </li>-</ul>-</li>-<li>-<strong>non-functional</strong> - ~ 15% :-<ul>-<li>third most common</li>-<li>85-100% malignant</li>-<li>usually larger</li>- +</li>
- +<li>
- +<strong>other</strong><ul><li><a href="/articles/pancreatic-metastases">metastases to pancreas</a></li></ul>
- +</li>
- +</ul><h5>Exocrine tumours</h5><p> </p><ul>
- +<li>
- +<strong>ductal adenocarcinoma</strong> is by far the most common primary tumour, usually of the head (65%) and has a very poor prognosis.</li>
- +<li>
- +<strong>cystic neoplasms</strong> are further divided into: (with some overlap)<ul>
- +<li>unilocular<ul>
- +<li><a href="/articles/intraductal-papillary-mucinous-neoplasm">intraductal papillary mucinous neoplasms(IPMN)</a></li>
- +<li>
- +<a href="/articles/serous-cystadenoma-of-pancreas">serous cystadenoma</a> uncommonly uni/macro locular</li>
- +</ul>
- +</li>
- +<li>macrocystic - multilocular<ul>
- +<li>
- +<a href="/articles/mucinous-cystic-neoplasms-of-the-pancreas">mucinous cystic neoplasm</a> : usually body and tail</li>
- +<li><a href="/articles/intraductal-papillary-mucinous-neoplasm">intraductal papillary mucinous neoplasms (IPMN)</a></li>
- +<li>
- +<a href="/articles/serous-cystadenoma-of-pancreas">serous cystadenoma</a> uncommonly uni / macro locular</li>
- +</ul>
- +</li>
- +<li>microcystic<ul><li>
- +<a href="/articles/serous-cystadenoma-of-pancreas">serous cystadenoma</a> - usually head. 30% have a central scar</li></ul>
- +</li>
- +<li>cystic with a solid component<ul><li>macrocystic tumours can have solid component also</li></ul>
- +</li>
- +</ul>
- +</li>
- +<li>
- +<strong>generally solid </strong><ul><li><a href="/articles/solid-pseudopapillary-tumour-of-pancreas">solid-pseudopapillary tumour of pancreas</a></li></ul>
- +</li>
- +</ul><p><strong>See also </strong>- <a href="/articles/cystic-lesions-of-the-pancreas">cystic pancreatic mass : differential diagnosis</a></p><h5>Endocrine tumours</h5><p><a href="/articles/endocrine-tumours-of-the-pancreas">Endocrine tumours of the pancreas</a> are divided into :</p><ul>
- +<li>
- +<strong>functional</strong> - ~ 85 %<ul>
- +<li>
- +<a href="/articles/insulinoma">insulinoma</a> - most common. 10% are malignant</li>
- +<li>
- +<a href="/articles/gastrinoma">gastrinoma</a> - second most common. 60% malignant</li>
- +<li>
- +<a href="/articles/glucagonoma">glucagonoma</a> - 80% malignant</li>
- +<li>
- +<a href="/articles/vipoma">VIPoma</a> - 75% malignant</li>
- +<li>
- +<a href="/articles/somatinoma">somatostatinoma</a> - 75% malignant</li>
- +</ul>
- +</li>
- +<li>
- +<strong>non-functional</strong> - ~ 15% :<ul>
- +<li>third most common</li>
- +<li>85-100% malignant</li>
- +<li>usually larger</li>
-</li>-</ul><h5>- +</li>
- +</ul><h5>
-<li>lymphangioma</li>-<li>lipoma</li>-<li><a title="Pancreatoblastoma" href="/articles/pancreatoblastoma">pancreatoblastoma</a></li>-<li>teratoma</li>-<li><a href="/articles/pancreatic-lymphoma" title="Pancreatic lymphoma">lymphoma</a></li>-<li>schwannoma</li>-<li>neurofibroma</li>-<li>sarcoma</li>-</ul><h5><span>Classification based on location </span></h5><h6><strong>Head</strong></h6><ul>-<li><a href="/articles/serous-cystadenoma-of-pancreas" title="Serous cystadenoma of pancreas">serous cystadenoma</a></li>-<li><a href="/articles/intraductal-papillary-mucinous-neoplasm" title="Intraductal papillary mucinous neoplasms (IPMN)">intraductal papillary mucinous neoplasms (IPMN)</a></li>-<li><a href="/articles/pancreatic-ductal-carcinoma" title="Pancreatic ductal adenocarcinoma">ductal adenocarcinoma</a></li>-<li>-<a href="/articles/pancreatoblastoma">pancreatoblastoma</a> (rare and in children) </li>- +<li>lymphangioma</li>
- +<li>lipoma</li>
- +<li><a href="/articles/pancreatoblastoma">pancreatoblastoma</a></li>
- +<li>teratoma</li>
- +<li><a href="/articles/pancreatic-lymphoma">lymphoma</a></li>
- +<li>schwannoma</li>
- +<li>neurofibroma</li>
- +<li>sarcoma</li>
- +</ul><h5>Classification based on location </h5><h6><strong>Head</strong></h6><ul>
- +<li><a href="/articles/serous-cystadenoma-of-pancreas">serous cystadenoma</a></li>
- +<li><a href="/articles/intraductal-papillary-mucinous-neoplasm">intraductal papillary mucinous neoplasms (IPMN)</a></li>
- +<li><a href="/articles/pancreatic-ductal-carcinoma">ductal adenocarcinoma</a></li>
- +<li>
- +<a href="/articles/pancreatoblastoma">pancreatoblastoma</a> (rare and in children)</li>
-<li><a href="/articles/mucinous-cystic-neoplasms-of-the-pancreas">mucinous cystic neoplasms</a></li>-<li><a href="/articles/papillary_cystic_neoplasm_of_the_pancreas">papillary cystic neoplasm of the pancreas</a></li>- +<li><a href="/articles/mucinous-cystic-neoplasms-of-the-pancreas">mucinous cystic neoplasms</a></li>
- +<li><a href="/articles/papillary-cystic-neoplasm-of-the-pancreas">papillary cystic neoplasm of the pancreas</a></li>
Images Changes:
Image 3 MRI (T2 fat sat) ( create )
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