Articles

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16,925 results
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Mesenchymal chondrosarcoma

Mesenchymal chondrosarcomas (MCS) are rare highly malignant chondrosarcomas with a biphasic morphology of a primitive mesenchymal tumor and a well-differentiated cartilaginous component. Epidemiology Mesenchymal chondrosarcomas are rare tumors and make up for ~2-4% of all chondrosarcomas 1. Th...
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Osteochondroma

Osteochondromas are a relatively common imaging finding, accounting for 10-15% of all bone tumors and ~35% of all benign bone tumors. Although usually thought of as a benign bone tumor, they may be thought of as a developmental anomaly. They are frequently asymptomatic and have very low malignan...
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Boston criteria 2.0 for cerebral amyloid angiopathy

The Boston criteria 2.0 were proposed in 2022 in order to better include leptomeningeal and white matter characteristics into the diagnoses of probable and possible cerebral amyloid angiopathy (CAA) 1. They consist of combined clinical, imaging and pathological parameters, and are based upon the...
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Primary synovial chondromatosis

Primary synovial chondromatosis (also known as Reichel syndrome or Reichel-Jones-Henderson syndrome), is a benign monoarticular disorder of unknown origin that is characterized by synovial metaplasia and proliferation resulting in multiple intra-articular cartilaginous loose bodies of relatively...
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Acute flaccid myelitis

Acute flaccid myelitis is an uncommon cause of acute flaccid paralysis similar to poliomyelitis, primarily affecting children and usually seen following a respiratory viral illness.   Epidemiology Acute flaccid myelitis primarily affects children. Cases appear to be temporally related to respi...
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Juxtacortical chondroma

Juxtacortical chondromas, also known as periosteal chondromas, are rare benign chondral tumors that arise from the periosteum of tubular bones. They are thought to account for ~2% of benign bone tumors. Epidemiology They tend to present around the 2nd to 4th decades. There is a recognized male...
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Evaluation of recurrent bone tumors

Recurrent bone tumors are a common complication post curettage or resection. Radiographic features Radiographs taken pre- and postoperatively are sufficient for evaluation of recurrence based on the following features: osteolytic changes cortical changes matrix mineralization (characteristi...
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Prion diseases

Prion diseases, also known as transmissible spongiform encephalopathies, are caused by the accumulation of dysmorphic proteins named prions, and are characterized by progressive neurological decline and eventual death. In humans, prion diseases include: Creutzfeldt-Jakob disease (sporadic, var...
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Pulvinar sign (CNS)

The pulvinar sign refers to bilateral FLAIR hyperintensities involving the pulvinar thalamic nuclei 1,2. It is classically described in variant Creutzfeldt-Jakob disease and is part of the World Health Organization diagnostic criteria for this condition 2. The pulvinar sign may also be describe...
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Chondrosarcoma of the skull base

Chondrosarcomas of the base of the skull are rare compared with other skull base tumors but are an important differential diagnosis as surgical resection and management are affected by the preoperative diagnosis. Epidemiology Chondrosarcomas of the base of the skull make up only a small fracti...
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Duct of Rivinus

The duct of Rivinus, also known as the minor sublingual duct, drains saliva from the sublingual gland into the floor of the mouth. Despite its name, it is not a single duct, but numerous small ducts, all of which open into the floor of the mouth and are collectively termed the duct of Rivinus. ...
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Longitudinally extensive spinal cord lesion

Longitudinally extensive spinal cord lesions (LESCL), also known as longitudinally extensive transverse myelitis (LETM), represent extensive involvement of the spinal cord, with abnormal T2 signal traversing at least three vertebral body segments in length. Pathology There are many potential c...
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Hockey stick sign (Creutzfeldt-Jakob disease)

The hockey stick sign is an MRI imaging feature most commonly associated with Creutzfeldt-Jakob disease. It describes the combination of the pulvinar sign (forming the blade/head of the stick) along with involvement of the medial thalamus (forming the shaft). A similar appearance can be seen in...
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Ageusia

Ageusia refers to a complete loss of taste. In instances where it is partial it is then falls under the spectrum of the conditions such as hypogeusia (decreased sensitivity to all tastants) hyperguesia (enhanced gustatory sensitivity) dysgeusia (unpleasant perception of a tastant) and phanto...
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Aquaporin

Aquaporin is a family of transmembrane water channels found throughout the body of both humans and many other species, facilitating the passage of water, cations and gases 1.  At least thirteen types of aquaporin have been described, and these are variably expressed. Aquaporin-4 Aquaporin-4 (...
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Neuromyelitis optica spectrum disorder

Neuromyelitis optica spectrum disorder (NMOSD) is a severe demyelinating diseases, which in seropositive cases, is caused by an autoantibody to the aquaporin-4 (AQP4) water channel. The classic presentation of NMOSD is with the triad of optic neuritis, longitudinally extensive myelitis, and posi...
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Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an autosomal dominant microvasculopathy characterized by recurrent lacunar and subcortical white matter ischemic strokes and vascular dementia in young and middle age patients without known va...
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Talar neck fracture

Talar neck fractures extend through the thinnest cross-sectional portion of the talus, just proximal to the talar head. They represent one of the most common types of talus fracture (~30-50%), along with chip and avulsion fractures of the talus (~40-49%). These fractures are commonly associated ...
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Ankle radiograph (checklist)

The ankle radiograph checklist is just one of the many pathology checklists that can be used when reporting to ensure that you always actively exclude pathology that is commonly missed; this is particularly helpful in the examination setting, e.g. the FRCR 2B rapid-reporting. Radiograph The ma...
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Enchondromatosis

Enchondromatosis, also known as Ollier disease (see Terminology section), is a non-hereditary, sporadic, skeletal disorder characterized by multiple enchondromas principally located in the metaphyseal regions. Terminology Some authors make a distinction between Ollier disease and enchondromato...

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