Splenic amyloidosis
Updates to Article Attributes
Body
was changed:
Splenic amyloidosis is a rare as an isolated entity. Most often it is associated with either systemic amyloidosis or hepatic amyloidosis. In general splenic involvement in amyloidosis is rather rather frequent (5-10% of cases 6)
Clinical presentation
Symptoms include
- abdominal mass
-
and/or abdominal
discomfort pain in left hypochondrium
(left upper quadrant) pain.
Radiographic features
Plain filmradiograph
Not sensitive of specific but may show splenomegaly
CT
- splenomegaly
- non contrast CT shows ill-defined heterogenous lesions
- post contrast CT shows heterogenous enhancement and hypoperfusion of spleen is one of the important indicator of systemic amyloidosis
MRI
May
- may show splenomegaly
-
T2:
-affected regions may show decreased signal intensity 1
Complications
- atraumatic splenic rupture 6
Differential diagnosis
Imaging differential considerations include splenic involvement with
See also
-<p><strong>Splenic amyloidosis</strong> is a rare as an isolated entity. Most often it is associated with either systemic <a href="/articles/amyloidosis" title="Amyloidosis (general)">amyloidosis</a> or <a href="/articles/hepatic-amyloidosis" title="Hepatic amyloidosis">hepatic amyloidosis</a>. In general splenic involvement in amyloidosis is rather frequent (5-10% of cases <sup>6</sup>)</p><h4>Clinical presentation</h4><p>Symptoms include</p><ul>-<li>abdominal mass</li>-<li>abdominal discomfort</li>-<li>pain in left hypochondrium</li>-</ul><h4>Radiographic features</h4><h5>Plain film</h5><p>Not sensitive of specific but may show splenomegaly</p><h5>CT </h5><ul>-<li>splenomegaly</li>-<li>non contrast CT shows ill-defined heterogenous lesions </li>-<li>post contrast CT shows heterogenous enhancement and hypoperfusion of spleen is one of the important indicator of systemic amyloidosis</li>-</ul><h5>MRI</h5><p>May show splenomegaly</p><p></p><ul><li>-<strong>T2</strong> - affected regions may show decreased signal intensity <sup>1</sup>-</li></ul><h4>Complications</h4><ul><li>atraumatic <a href="/articles/splenic-rupture" title="splenic rupture">splenic rupture</a> <sup>6</sup>- +<p><strong>Splenic amyloidosis</strong> is rare as an isolated entity. Most often it is associated with either systemic <a href="/articles/amyloidosis">amyloidosis</a> or <a href="/articles/hepatic-amyloidosis">hepatic amyloidosis</a>. In general splenic involvement in amyloidosis is rather frequent (5-10% of cases <sup>6</sup>)</p><h4>Clinical presentation</h4><p>Symptoms include abdominal mass and/or abdominal (left upper quadrant) pain.</p><p><strong style="font-size:1.5em; font-weight:bold; line-height:1em">Radiographic features</strong></p><h5>Plain radiograph</h5><p>Not sensitive of specific but may show <a title="Splenomegaly" href="/articles/splenomegaly">splenomegaly</a></p><h5>CT </h5><ul>
- +<li>splenomegaly</li>
- +<li>non contrast CT shows ill-defined heterogenous lesions </li>
- +<li>post contrast CT shows heterogenous enhancement and hypoperfusion of spleen is one of the important indicator of systemic amyloidosis</li>
- +</ul><h5>MRI</h5><ul>
- +<li>may show splenomegaly</li>
- +<li>
- +<strong>T2: </strong>affected regions may show decreased signal intensity <sup>1</sup>
- +</li>
- +</ul><h4>Complications</h4><ul><li>atraumatic <a href="/articles/splenic-rupture">splenic rupture</a> <sup>6</sup>
-<li><a href="/articles/splenic-tumours" title="splenic tumours">splenic tumours</a></li>-<li><a href="/articles/chronic-myeloid-leukaemia" title="chronic myeloid leukaemia">chronic myeloid leukaemia</a></li>-</ul><h4>See also</h4><ul><li><a href="/articles/splenic-lesions-and-anomalies" title="Splenic lesions and anomalies">splenic lesions and anomalies</a></li></ul>- +<li><a href="/articles/splenic-tumours">splenic tumours</a></li>
- +<li><a href="/articles/chronic-myeloid-leukaemia">chronic myeloid leukaemia</a></li>
- +</ul><h4>See also</h4><ul><li><a href="/articles/splenic-lesions-and-anomalies">splenic lesions and anomalies</a></li></ul>
Unable to process the form. Check for errors and try again.