Splenic amyloidosis
Updates to Article Attributes
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was changed:
Splenic amyloidosis is rare as an isolated entity. Most often it is associated with either systemic amyloidosis or hepatic amyloidosis.
Epidemiology
In general, splenic involvement in amyloidosis is rather frequent (5-10% of cases 6,7).
Clinical presentation
Symptoms include abdominal mass and abdominal (leftleft upper quadrant) pain pain.
Complications
- atraumatic splenic rupture 6
Radiographic features
Plain radiograph
Not sensitive of specific but may show splenomegaly.
CT
- splenomegaly
- calcification is rarely seen 7
- non-contrast CT shows ill-defined heterogeneous lesions
- post
contrast-contrast CT shows heterogeneous enhancement and hypoperfusion of spleen, which is one of the important indicators of systemic amyloidosis
MRI
- splenomegaly
- T2: affected regions may show decreased signal intensity 1,7
Differential diagnosis
Imaging differential considerations include splenic involvement with:
- splenic tumours
- chronic myeloid leukaemia
- iron overload
See also
-<p><strong>Splenic amyloidosis</strong> is rare as an isolated entity. Most often it is associated with either systemic <a href="/articles/amyloidosis">amyloidosis</a> or <a href="/articles/hepatic-amyloidosis">hepatic amyloidosis</a>.</p><h4>Epidemiology</h4><p>In general splenic involvement in amyloidosis is rather frequent (5-10% of cases <sup>6</sup>).</p><h4>Clinical presentation</h4><p>Symptoms include abdominal mass and abdominal (left upper quadrant) pain.</p><h5>Complications</h5><ul><li>atraumatic <a href="/articles/splenic-rupture">splenic rupture</a> <sup>6</sup>- +<p><strong>Splenic amyloidosis</strong> is rare as an isolated entity. Most often it is associated with either systemic <a href="/articles/amyloidosis">amyloidosis</a> or <a href="/articles/hepatic-amyloidosis">hepatic amyloidosis</a>.</p><h4>Epidemiology</h4><p>In general, splenic involvement in amyloidosis is rather frequent (5-10% of cases <sup>6,7</sup>).</p><h4>Clinical presentation</h4><p>Symptoms include abdominal mass and left upper quadrant pain.</p><h5>Complications</h5><ul><li>atraumatic <a href="/articles/spontaneous-splenic-rupture">splenic rupture</a> <sup>6</sup>
- +<li>calcification is rarely seen <sup>7</sup>
- +</li>
-<li>post contrast CT shows heterogeneous enhancement and hypoperfusion of spleen, which is one of the important indicators of systemic amyloidosis</li>- +<li>post-contrast CT shows heterogeneous enhancement and hypoperfusion of spleen, which is one of the important indicators of systemic amyloidosis</li>
-<strong>T2: </strong>affected regions may show decreased signal intensity <sup>1</sup>- +<strong>T2: </strong>affected regions may show decreased signal intensity <sup>1,7</sup>
-</ul><h4>See also</h4><ul><li><a href="/articles/splenic-lesions-and-anomalies">splenic lesions and anomalies</a></li></ul>- +<li>iron overload </li>
- +</ul>
References changed:
- 7. Özcan HN, Haliloğlu M, Sökmensüer C, Akata D, Özmen M, Karçaaltıncaba M. Imaging for abdominal involvement in amyloidosis. (2017) Diagnostic and interventional radiology (Ankara, Turkey). 23 (4): 282-285. <a href="https://doi.org/10.5152/dir.2017.16484">doi:10.5152/dir.2017.16484</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/28498108">Pubmed</a> <span class="ref_v4"></span>
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