Splenic amyloidosis
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Splenic amyloidosis is rare as an isolated entity. Most often it is associated with either systemic amyloidosis or hepatic amyloidosis.
Epidemiology
In general, splenic involvement in amyloidosis is rather frequent (5-10% of cases 6,7).
Clinical presentation
Symptoms include abdominal mass and left upper quadrant pain.
Complications
- atraumatic splenic rupture 6
Radiographic features
Plain radiograph
Not sensitive ofor specific but may show splenomegaly.
CT
- splenomegaly
- calcification is rarely seen 7
- non-contrast CT shows ill-defined heterogeneous lesions
- post-contrast CT shows heterogeneous enhancement and hypoperfusion of spleen, which is one of the important indicators of systemic amyloidosis
MRI
- splenomegaly
- T2: affected regions may show decreased signal intensity 1,7
Differential diagnosis
Imaging differential considerations include splenic involvement with:
- splenic tumours
- chronic myeloid leukaemia
- iron overload
-</li></ul><h4>Radiographic features</h4><h5>Plain radiograph</h5><p>Not sensitive of specific but may show <a href="/articles/splenomegaly">splenomegaly</a>.</p><h5>CT </h5><ul>- +</li></ul><h4>Radiographic features</h4><h5>Plain radiograph</h5><p>Not sensitive or specific but may show <a href="/articles/splenomegaly">splenomegaly</a>.</p><h5>CT </h5><ul>
-<li>calcification is rarely seen <sup>7</sup>- +<li>
- +<a title="Splenic calcification" href="/articles/splenic-calcification">calcification</a> is rarely seen <sup>7</sup>
-<li>non-contrast CT shows ill-defined heterogeneous lesions </li>- +<li>non-contrast CT shows ill-defined heterogeneous lesions</li>
-<li>iron overload </li>- +<li>iron overload</li>
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