Glioblastoma NOS (multicentric)
Diagnosis almost certain
Updates to Case Attributes
Title
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Glioblastoma: multicentric NOS (multicentric)
Body
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Histopathology of the largest lesion revealed WHO grade IV glioblastoma with pleomorphic astrocytes and marked atypia and mitotic figures. The frontal lesion does not appear to be connected to the occipital lesions by abnormal T2 signal, and thus the term multicentric glioblastoma would be favoured over multifocal.
Note:IDH mutation status is not provided in this case and according to the current (2016) WHO classification of CNS tumours, this tumour would, therefore, be designated as a glioblastoma NOS.
-<p>Histopathology of the largest lesion revealed WHO grade IV <a href="/articles/glioblastoma">glioblastoma</a> with pleomorphic astrocytes and marked atypia and mitotic figures. The frontal lesion does not appear to be connected to the occipital lesions by abnormal T2 signal, and thus the term <a title="Multicentric glioblastoma" href="/articles/multicentric-glioblastoma">multicentric glioblastoma</a> would be favoured over multifocal. </p>- +<p>Histopathology of the largest lesion revealed WHO grade IV <a href="/articles/glioblastoma">glioblastoma</a> with pleomorphic astrocytes and marked atypia and mitotic figures. The frontal lesion does not appear to be connected to the occipital lesions by abnormal T2 signal, and thus the term <a href="/articles/multicentric-glioblastoma">multicentric glioblastoma</a> would be favoured over multifocal. </p><p><strong>Note:</strong> <a href="/articles/isocitrate-dehydrogenase-idh">IDH mutation</a> status is not provided in this case and according to the current (2016) <a href="/articles/who-classification-of-cns-tumours-1">WHO classification of CNS tumours</a>, this tumour would, therefore, be designated as a <a href="/articles/glioblastoma-nos">glioblastoma NOS</a>. </p>
Diagnostic Certainty
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