A.Prof Frank Gaillard et al.

S100 is a family of cytoplasmic calcium-binding proteins expressed in numerous cell lines which can be targetted by immunohistochemistry. Staining for S100 is helpful in characterising a number of tumours, including malignant melanoma, glial tumours, neurogenic tumours (e.g. schwannomas and neurofibromas), mesenchymal tumours (e.g. chondromas, chondrosarcomas, liposarcomas, some osteogenic sarcomas) and some histiocytic tumours 1,2

History and etymology

S100 is a contracture of 100% soluble in ammonium sulphate at neutral pH 3

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Article information

rID: 52074
Section: Pathology
Synonyms or Alternate Spellings:

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