S100
Citation, DOI, disclosures and article data
Citation:
Gaillard F, Bell D, Campos A, et al. S100. Reference article, Radiopaedia.org (Accessed on 01 Mar 2025) https://doi.org/10.53347/rID-52074
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rID:
52074
Article created:
Disclosures:
At the time the article was created Frank Gaillard had no recorded disclosures.
View Frank Gaillard's current disclosures
Last revised:
Disclosures:
At the time the article was last revised Daniel J Bell had no financial relationships to ineligible companies to disclose.
View Daniel J Bell's current disclosures
Revisions:
7 times, by
5 contributors -
see full revision history and disclosures
Systems:
Sections:
Synonyms:
- S100 protein
- S-100
S100 is a family of cytoplasmic calcium-binding proteins expressed in numerous cell lines which can be targeted by immunohistochemistry. Staining for S100 is helpful in characterizing a number of tumors, including malignant melanoma, glial tumors, neurogenic tumors (e.g. schwannomas and neurofibromas), mesenchymal tumors (e.g. chondromas, chondrosarcomas, liposarcomas, some osteogenic sarcomas) and some histiocytic tumors 1,2.
History and etymology
S100 is a contracture of "100% soluble" in ammonium sulfate at neutral pH 3.
Quiz questions
References
- 1. Schmitt F & Bacchi C. S-100 Protein: Is It Useful as a Tumour Marker in Diagnostic Immunocytochemistry? Histopathology. 1989;15(3):281-8. doi:10.1111/j.1365-2559.1989.tb03078.x - Pubmed
- 2. Cochran AJ, Wen DR. S-100 protein as a marker for melanocytic and other tumours. Pathology. 17 (2): 340-5. Pubmed
- 3. Jose A. Plaza, Victor G. Prieto. Applied Immunohistochemistry in the Evaluation of Skin Neoplasms. (2016) ISBN: 9783319305905 - Google Books
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