S100

S100 is a family of cytoplasmic calcium-binding proteins expressed in numerous cell lines which can be targetted by immunohistochemistry. Staining for S100 is helpful in characterising a number of tumours, including malignant melanoma, glial tumours, neurogenic tumours (e.g. schwannomas and neurofibromas), mesenchymal tumours (e.g. chondromas, chondrosarcomas, liposarcomas, some osteogenic sarcomas) and some histiocytic tumours 1,2

History and etymology

S100 is a contracture of 100% soluble in ammonium sulphate at neutral pH 3


Share article

Article Information

rID: 52074
Section: Pathology
Synonyms or Alternate Spellings:

Support Radiopaedia and see fewer ads

Updating… Please wait.
Loadinganimation

Alert accept

Error Unable to process the form. Check for errors and try again.

Alert accept Thank you for updating your details.