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Nothnagel syndrome is a rare midbrain syndrome that involves the tectum of the midbrain (quadrigeminal plate) and superior cerebellar peduncles 1-4,6.
Although it can be caused by stroke, especially hemorrhages rather than infarctions, it is more commonly seen due to neoplasm extending from the tectal plate into the superior cerebellar peduncles 1-4,6.
Lesions are in the tectum of the midbrain with imaging characteristics depending on the underlying cause.
History and etymology
The syndrome was first described by Hermann Nothnagel (1841-1905), a German-Austrian physician, in 1879 5.
- 1. Liu GT, Crenner CW, Logigian EL, Charness ME, Samuels MA. Midbrain syndromes of Benedikt, Claude, and Nothnagel: setting the record straight. Neurology. 42 (9): 1820-2. Pubmed
- 2. Ropper AH, Samuels MA, Klein JP. Adams and Victor's principles of neurology 10th ed. New York: McGraw-Hill Medical Pub. Division; 2014.
- 3. Patten J. Neurological differential diagnosis 2nd ed. Springer Science & Business Media; 1996.
- 4. Moncayo J. Midbrain infarcts and hemorrhages. Frontiers of neurology and neuroscience. 30: 158-61. doi:10.1159/000333630 - Pubmed
- 5. Nothnagel H. Corpora quadrigemina. In: Topische Diagnostik der Gehirnkrankheiten. A Hirschwald, 1879:204-220.
- 6. Sara Sciacca, Jeremy Lynch, Indran Davagnanam, Robert Barker. Midbrain, Pons, and Medulla: Anatomy and Syndromes. (2019) RadioGraphics. 39 (4): 1110-1125. doi:10.1148/rg.2019180126 - Pubmed