Medial medullary syndrome

Last revised by Dr Bahman Rasuli on 15 Oct 2021

Medial medullary syndrome, also known as jerine syndrome,  is secondary to thrombotic or embolic occlusion of small perforating branches from vertebral or proximal basilar artery supplying the medial aspect of medulla oblongata1,2.

Represents less than 1% of brainstem stroke syndromes 1,2.

It is characterized by contralateral hemiplegia/hemiparesis as well as hemisensory loss with ipsilateral hypoglossal palsy (ipsilateral tongue weakness and atrophy) from involvement of CN XII nucleus 1,2. Other manifestations such as vertigo, nausea, or contralateral limb ataxia are also reported 1,2.

The syndrome was first described by Joseph Jules Déjerine (1849-1917), a French neurologist, in 1915 3.

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Cases and figures

  • Case 1
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  • Case 2
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  • Case 3
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  • Case 4
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  • Case 5: bilateral - with heart sign
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