Medial medullary syndrome
Citation, DOI & article data
Medial medullary syndrome, also known as Déjerine syndrome, is secondary to thrombotic or embolic occlusion of small perforating branches from vertebral or proximal basilar artery supplying the medial aspect of medulla oblongata1,2.
Represents less than 1% of brainstem stroke syndromes 1,2.
It is characterized by contralateral hemiplegia/hemiparesis as well as hemisensory loss with ipsilateral hypoglossal palsy (ipsilateral tongue weakness and atrophy) from involvement of CN XII nucleus 1,2. Other manifestations such as vertigo, nausea, or contralateral limb ataxia are also reported 1,2.
History and etymology
The syndrome was first described by Joseph Jules Déjerine (1849-1917), a French neurologist, in 1915 3.
- 1. Bassetti C, Bogousslavsky J, Mattle H et-al. Medial medullary stroke: report of seven patients and review of the literature. Neurology. 1997;48 (4): 882-90. Pubmed citation
- 2. Ropper AH, Samuels MA, Klein JP. Adams and Victor's principles of neurology 10th ed. New York: McGraw-Hill Medical Pub. Division; 2014.
- 3. Dejerine J. Semiologie des affections du systeme nerveux. The Journal of Nervous and Mental Disease. 1915 Nov 1;42(11):780.