Post-primary pulmonary tuberculosis

Post-primary tuberculosis, also known as reactivation tuberculosis or secondary tuberculosis usually occurs during the two years following the initial infection. Reactivation frequently occurs in the setting of decreased immunity and usually involves the lung apex. 

Pathology

Location
  • apical and posterior segments of the upper lobe
  • superior segment of lower lobe 

Radiographic features

CT
Parenchymal disease
  • ill-defined patchy consolidation 
  • clustered parenchymal opacification may give rise to a galaxy sign
  • cavitation usually develops within the consolidation
  • fibroproliferative disease with coarse reticulonodular densities
  • endobronchial spread with "tree-in-bud" appearance, best appreciated on HRCT
  • healing results in fibrosis, volume loss and traction bronchiectasis
  • lymphadenopathy occurs only in 5% cases
Airway disease

Central airway involvement results in bronchial stenosis which may lead to lobar collapse associated with traction bronchiectasis and mucoid impaction. 

Pleural disease
  • occurs in a minority of cases (18%)
  • small pleural effusion
  • pleural thickening
  • pleural calcification
Chest wall involvement

Chest wall involvement occurring due to direct extension from pulmonary disease manifests as bone and/or cartilage destruction and cutaneous fistula formation.

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Article information

rID: 17867
System: Chest
Section: Pathology
Synonyms or Alternate Spellings:
  • Reactivation tuberculosis
  • Reactivation TB
  • Post-primary TB

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