Goitre

Dr Daniel J Bell and Dr Henry Knipe et al.

Goitre (rarely thyromegaly) refers to enlargement of the thyroid gland. It can occur from multiple conditions. Clearly the absence of thyroid enlargement does not preclude significant thyroid pathology.

The definition of a goitre depends on age and sex; below are the upper limits of normal for thyroid gland volume 1:

  • adult males: 25 mL
  • adult females: 18 mL
  • 13-14 years: 8-10 mL
  • 3-4 years: 3 mL
  • neonate: 0.8-1.5 mL

The prevalence of goitre varies widely depending on the level of iodine deficiency. In severely iodine-deficient areas the prevalence may be as a high as 80%. Goitre is more common in women (M:F = 1:4) and incidence declines with age 5.

The thyroid gland may become so enlarged that it becomes a substernal (retrosternal) goitre.

The causes of goitre are diverse 2,3:

  • each lobe normally measures 4:
    • length: 4-7 cm
    • depth: <2 cm
    • isthmus ≤0.5 cm deep

Thyroid volume can be estimated by measuring each lobe and applying the following correction factor for an ellipsoid formula 6:

  • height (cm) x width (cm) x depth (cm) x 0.529*

* various correction factors between 0.494-0.554 have also been proposed 6

  • volume (excluding isthmus, unless its thickness is >3 mm) 6
    • 10-15 mL for females
    • 12-18 mL for males

Goitre derives from the old French "goitron" meaning gullet. Goitron comes from the Latin "guttur" meaning throat.

See main article: midline neck mass

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Article information

rID: 32226
System: Head & Neck
Synonyms or Alternate Spellings:
  • Enlargement of the thyroid gland
  • Goiters
  • Goitres
  • Thyromegaly
  • Enlarged thyroid
  • Thyroid enlargement
  • Goiter
  • Thyroidomegaly

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Cases and figures

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    Case 1: multinodular goitre
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    Case 2: nodular Graves' disease
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    Case 3: Hashimoto thyroiditis
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    Case 4: multinodular goitre
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    Case 5
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    Case 6
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    Case 7: retrosternal
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    Case 8
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