Aspergilloma

Dr Ian Bickle and A.Prof Frank Gaillard et al.

Aspergillomas are mass-like fungus balls that are typically composed of Aspergillus fumigatus, and are a non-invasive form of pulmonary aspergillosis.

Although the term mycetoma is frequently used to describe these fungal balls, it is an incorrect term to use 5-6.

Aspergillomas occur in patients with normal immunity but structurally abnormal lungs, with pre-existing cavities. Demographics will therefore match those of the underlying condition, such as 2:

Most aspergillomas are asymptomatic. Occasionally due to surrounding reactive vascular granulation tissue, haemoptysis may be present. Occasionally, erosion into a bronchial artery may lead to life-threatening haemoptysis 1.

An aspergilloma is a mass-like collection of fungal hyphae, mixed with mucous and cellular debris, within a cavity the walls of which demonstrate vascular granulation tissue 1-2.

Aspergillomas typically occur in the cavities of post-primary pulmonary tuberculosis. Therefore, they are most frequently found in the posterior segments of the upper lobes and the superior segments of the lower lobes.

A mycetoma can be seen on both plain film and CT as an intracavitary mass surrounded by a crescent of air. The term "air-crescent" is however really seen in recovering invasive pulmonary aspergillosis. It is wrongly used by many to describe the air around an aspergilloma. The correct term to describe the crescent of air is the Monad sign in the setting of aspergilloma developing in a pre-existing cavity, although it is less widely recognised.

Aspergillomas typically appear as rounded or ovoid soft tissue attenuating masses located in a surrounding cavity and outlined by a crescent of air 1-4. Altering the position of the patient usually demonstrates that the mass is mobile, thus confirming the diagnosis.

Appearances are those of a well formed cavity with a central soft tissue attenuating rounded mass surrounded by a crescent of air (Monad sign). The mass is typically spherical or ovoid. On different positioning of the patient, the mass can be shown to be mobile. On occasion the mass may entirely fill the cavity, thus taking on the shape of the cavity, obliterating the surrounding air crescent and no longer being mobile 2.

Calcification is not uncommon, which can range from none to heavy. Due to the inflammation and vascular granulation tissue formation, the bronchial arteries supplying the wall can sometimes be seen as markedly enlarged 2.

The adjacent pleura may well be thickened.

An asymptomatic aspergilloma does not necessarily require treatment, and the cavity is essentially isolated from any systemic administration of anti-fungals 3.

In the setting of brisk haemoptysis, angiography may be performed on an emergency basis and selective bronchial artery embolisation can be life saving. Failing this, or in cases of repeated haemoptysis surgical excision with a lobectomy remains the gold standard 3.

Mortality rate varies widely, but in more recent series is low, even where requiring surgery 3.

When classical in appearance there is little differential. If the mass fills the cavity completely then the differential is that of solitary pulmonary nodule.

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Article information

rID: 8680
System: Chest
Synonyms or Alternate Spellings:
  • Saprophytic aspergillosis
  • Aspergillomas

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Cases and figures

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    Figure 1: gross pathology
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    Aspergilloma
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    Figure 2: Aspergillus fumigatus - microbiology
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    Monad's sign of f...
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