Middle East Respiratory Syndrome coronavirus (MERS-CoV)

Dr Henry Knipe et al.

Middle East Respiratory Syndrome coronavirus (MERS-CoV) infection is an uncommon viral infection (<1000 cases) with the first case reported in Saudi Arabia in 2012. It most commonly causes pneumonia and acute renal failure with a mortality rate of ~40%. MERS-CoV raises concern because of its similarity to SARS-CoV infection, with similar spread via infected cases who travel by air. 

MERS-CoV primary cases have been isolated to the Middle East (most commonly Saudi Arabia), travel-related cases have been reported in western Europe, North America and eastern Asia 3,5. The average age is ~50 years with a slight male predominance of 1.5:1 3

The infection may be subclinical. If symptomatic features range from mild upper respiratory tract coryzal symptoms (high fever, cough) to severe respiratory distress and multiorgan failure 3,4. Vomiting and diarrhoea are also a feature 3.  

MERS-CoV belongs to lineage C of β-coronavirus, the first known to infect humans, and is a single-stranded RNA virus 4. The origin and mode of transmission is unclear but bats may be the original source and transmission suspected to be via camels 3,4,5. Human-to-human transmission is thought to occur and be responsible for the international spread 4,5

MERS-CoV infection can result in:

The radiographic features of MERS-CoV infection can be variable due to the variability in the severity of disease 7.

Plain radiographs

Reported chest x-ray features in a case series of 55 patients 8

CT

Reported CT chest features in a case series of seven patients 6

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Article Information

rID: 39692
System: Chest
Sections: Pathology, Syndromes
Synonyms or Alternate Spellings:
  • Middle Eastern respiratory syndrome (MERS)
  • Middle East Respiratory Syndrome coronavirus (MERS-CoV)

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