Weber syndrome
Citation, DOI, disclosures and article data
Citation:
Gaillard F, Elfeky M, Hacking C, et al. Weber syndrome. Reference article, Radiopaedia.org (Accessed on 08 Mar 2025) https://doi.org/10.53347/rID-2284
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2284
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Disclosures:
At the time the article was created Frank Gaillard had no recorded disclosures.
View Frank Gaillard's current disclosures
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At the time the article was last revised Mostafa Elfeky had no recorded disclosures.
View Mostafa Elfeky's current disclosures
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Synonyms:
- Weber's syndrome
Weber syndrome is a midbrain stroke syndrome that involves the cerebral peduncle and the ipsilateral fascicles of the oculomotor nerve 1-3,5. Occasionally the substantia nigra can also be involved 5.
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Clinical presentation
- ipsilateral CN III palsy
- diplopia
- ptosis
- afferent pupillary defect
- contralateral hemiplegia or hemiparesis
- involvement of the corticospinal and/or corticobulbar tracts
- contralateral parkinsonian rigidity (only if substantia nigra involved) 5
Pathology
It is usually caused by an ischemic stroke, typically involving branches of the posterior cerebral artery 1-3.
Radiographic features
Imaging may be helpful to connect the neurological symptoms with a single causative lesion.
The imaging appearance of Weber and Benedikt syndromes may be similar, as both result from an insult to the oculomotor nuclear complex 1-3, however the latter syndrome also involves the red nucleus in the midbrain tegmentum.
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History and etymology
The syndrome was first described by Sir Hermann Weber (1823-1918), a German-born English physician, in 1863 4.
References
- 1. Cormier PJ, Long ER, Russell EJ. MR imaging of posterior fossa infarctions: vascular territories and clinical correlates. Radiographics. 1992;12 (6): 1079-96. doi:10.1148/radiographics.12.6.1439013 - Pubmed citation
- 2. Jacobs DA, Galetta SL. Neuro-ophthalmology for neuroradiologists. AJNR Am J Neuroradiol. 2007;28 (1): 3-8. Pubmed citation
- 3. Allan Ropper, Joshua Klein, Martin Samuels. Adams and Victor's Principles of Neurology 10th Edition. (2014) ISBN: 9780071794794 - Google Books
- 4. Weber H. A Contribution to the Pathology of the Crura Cerebri. Medico-chirurgical transactions. 46: 121-140.1. Pubmed
- 5. Sara Sciacca, Jeremy Lynch, Indran Davagnanam, Robert Barker. Midbrain, Pons, and Medulla: Anatomy and Syndromes. (2019) RadioGraphics. 39 (4): 1110-1125. doi:10.1148/rg.2019180126 - Pubmed
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intracranial hemorrhage
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intra-axial hemorrhage
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intra-axial hemorrhage
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