AIDS-related pulmonary lymphoma

AIDS related pulmonary lymphoma (ARPL) is classified as a distinct form of pulmonary lymphoma. Pulmonary involvement is a common extranodal site in AIDS-related NHL.

ARPL is typically a high-grade B-cell non-Hodgkin's lymphoma and the majority of patients have advanced HIV infection, with a mean CD4 count of around 67 3.

Diagnositc criteria

According to some publications, the diagnostic criteria for pulmonary requires 2:

  • positive HIV status
  • histologically proven lymphomatous pulmonary involvement
  • absence of mediastinal and/or hilar adenopathy on chest radiography
  • absence of extrathoracic lymphoma extension
CT - HRCT chest

Features can be variable and can include:

  • multiple peripheral well-defined nodules of varying sizes
    • usually measure around 1-5 cm in diameter
    • these reflect dense focal monomorphic cellular infiltrates
    • considered the commonest of manifestations 1,4
  • centrilobular nodules
  • subpleural parenchymal infiltrative changes
  • peribronchovascular reticular infiltrative changes 4
  • peripheral mass like regions (may have associated cavitation).
  • interlobular septal thickening

Lymphoma
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Article Information

rID: 26218
Systems: Chest, Haematology
Section: Pathology
Tag: cases
Synonyms or Alternate Spellings:
  • AIDS related primary pulmonary lymphoma
  • AIDS related pulmonary lymphoma (ARL)
  • AIDS related pulmonary lymphoma (ARL-ARPL)
  • AIDS related pulmonary lymphoma (ARPL)
  • AIDS associated pulmonary lymphoma

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