Mantle cell lymphoma

Mantle cell lymphoma (MCL) is a type of non Hodgkin lymphoma (NHL) and accounts for ~5% of all NHL. It is a malignant neoplasm of virgin B cells that closely resemble normal mantle zone B cells surrounding germinal centres.

They occur in older adults (mean age ~60 years). There is a recognised male predilection (M:F of ~4:1) 2.

MCL is usually widespread at diagnosis and frequently involves, apart from lymph nodes, the spleen, bone marrow, and gastrointestinal tract.

MCL is characterised by an infiltrate of small to medium-sized cells with folded nuclei and scanty cytoplasm. The diagnosis of MCL was confirmed by histological assessment and immunohistochemical evaluation, including cyclin D1.

Genetics

Many cases have the t(11;14)(q13;q32) translocation that causes an over expression of cyclin-D1 2.

The survival is short with a ~50% 5-year survival. Over one-third of the patients can die within a year despite the administration of aggressive combination chemotherapy.


Lymphoma
Share article

Article Information

rID: 11065
Section: Pathology
Synonyms or Alternate Spellings:
  • Lymphoma - mantle cell
  • Mantle cell lymphoma (MCL)

Support Radiopaedia and see fewer ads

Cases and Figures

  • Drag
    Case 1: showing para-aortic involvement
    Drag here to reorder.
  • Updating… Please wait.
    Loadinganimation

    Alert accept

    Error Unable to process the form. Check for errors and try again.

    Alert accept Thank you for updating your details.