It should be differentiated from other non-tumour conditions associated with lymphoma that also affect the peripheral nervous system, such as irradiation, chemotherapy, or paraneoplastic effects.
NL seems to be the least common neurologic manifestation of lymphoma 3.
The symptoms may vary broadly, including painful plexopathy, cranial nerve palsies with or without pain, painful or painless mononeuropathy, and foot drop 1,3.
Brain or spinal MRI can spot a nerve or root enlargement and/or enhancement 1,3, sometimes with a nodular thickening.
- 1. Gan HK, Azad A, Cher L et-al. Neurolymphomatosis: diagnosis, management, and outcomes in patients treated with rituximab. Neuro-oncology. 2010;12 (2): 212-5. doi:10.1093/neuonc/nop021 - Free text at pubmed - Pubmed citation
- 2. Hughes RA, Britton T, Richards M. Effects of lymphoma on the peripheral nervous system. J R Soc Med. 1994;87 (9): 526-30. Free text at pubmed - Pubmed citation
- 3. Baehring JM, Damek D, Martin EC et-al. Neurolymphomatosis. Neuro-oncology. 2003;5 (2): 104-15. Free text at pubmed - Pubmed citation
- overview of lymphoma
WHO classification of tumours of haematopoietic and lymphoid tissues
- Hodgkin lymphoma
mature B-cell lymphoma
- Burkitt lymphoma
- follicular lymphoma
- lymphoplasmacytic lymphoma (Waldenström's macroglobulinaemia)
- lymphomatoid granulomatosis
- mantle cell lymphoma
- mature T-cell and NK-cell lymphoma
- post-transplant lymphoproliferative/lymphoproliferation disorders
- mature B-cell lymphoma
- location-specific lymphomas
- central nervous system
- head and neck lymphoma
- thoracic lymphoma
- gastrointestinal lymphoma
- hepatobiliary lymphoma
- genitourinary lymphoma
- musculoskeletal lymphoma
- cutaneous lymphoma
- lymphoma staging