Secondary hepatic involvement with lymphoma

Dr Tim Luijkx and Dr Henry Knipe et al.

Secondary hepatic involvement with lymphoma (secondary hepatic lymphoma) is common, much more so than primary hepatic lymphoma

Hepatomegaly with deranged liver function tests is the most common presentation. Jaundice is common. Rarely, patients may present with acute liver failure 4,5.

Hepatic involvement is more common at presentation in non-Hodgkin lymphoma (~20% of cases) than in Hodgkin lymphoma (~5% of cases) 4,6

Secondary hepatic lymphoma is typically diffusely infiltrating rather than a focal mass. It may sometimes have a miliary/nodular pattern. 

The liver is normal in ~25% of cases and features of secondary hepatic lymphoma are non-specific 2,3:

  • well-defined small nodular hypoechoic lesions
    • occasionally may be a "target lesion"
  • diffuse infiltrative disease
  • hepatomegaly (30%)
  • abdominal lymphadenopathy

Article information

rID: 33232
Synonyms or Alternate Spellings:
  • Secondary hepatic lymphoma

ADVERTISEMENT: Supporters see fewer/no ads

Cases and figures

  • Case 1: NHL
    Drag here to reorder.
  • Updating… Please wait.

     Unable to process the form. Check for errors and try again.

     Thank you for updating your details.