Secondary hepatic involvement with lymphoma (secondary hepatic lymphoma) is common, much more so than primary hepatic lymphoma.
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Clinical presentation
Hepatomegaly with deranged liver function tests is the most common presentation. Jaundice is common. Rarely, patients may present with acute liver failure 4,5.
Pathology
Hepatic involvement is more common at presentation in non-Hodgkin lymphoma (~20% of cases) than in Hodgkin lymphoma (~5% of cases) 4,6.
Radiographic features
Secondary hepatic lymphoma is typically diffusely infiltrating rather than a focal mass. It may sometimes have a miliary/nodular pattern.
Ultrasound
The liver is normal in ~25% of cases and features of secondary hepatic lymphoma are non-specific 2,3:
- well-defined small nodular hypoechoic lesions
- occasionally may be a "target lesion"
- diffuse infiltrative disease
-
hepatomegaly (30%)
- splenomegaly is often associated
- abdominal lymphadenopathy
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