Ann Arbor staging system

Dr Henry Knipe and Dr Jeffrey Cheng et al.

The Ann Arbor staging system is the landmark lymphoma staging classification system for both Hodgkin lymphoma and non-Hodgkin lymphoma

It is named after the town of Ann Arbor in the US state of Michigan where the Committee on Hodgkin's Disease Staging Classification met in 1971 to agree on it. It has since been updated and modified a number of times, notably as the Cotswolds-modified Ann Arbor classification, the Lugano classification and the most current LYRIC classification.

Staging system

  • stage I: involvement of a single lymph node region or of a single extralymphatic organ or site
  • stage II: involvement of two or more lymph node regions on the same side of the diaphragm or localised involvement of an extralymphatic organ or site 
  • stage III: involvement of lymph node regions or structures on both sides of the diaphragm
  • stage IV: diffuse or disseminated involvement of one or more extralymphatic organs, or either: 
    • isolated extralymphatic organ involvement without adjacent regional lymph node involvement, but with disease in distant sites
    • involvement of the liver, bone marrow, pleura or cerebrospinal fluid

Additional substaging variables include:

  • A: asymptomatic
  • B: presence of B symptoms (including fever, night sweats and weight loss of ≥10% of body weight over 6 months)
  • E: involvement of a single, extranodal site, contiguous or proximal to a known nodal site (stages I to III only; additional extranodal involvement is stage IV)
  • S: splenic involvement
  • X: bulky nodal disease: nodal mass >1/3 of intrathoracic diameter or 10 cm in dimension
Lymphoma
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Article information

rID: 63815
Synonyms or Alternate Spellings:
  • Ann Arbor classification system

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