Hodgkin lymphoma (pulmonary manifestations)
Citation, DOI, disclosures and article data
At the time the article was created Yuranga Weerakkody had no recorded disclosures.
View Yuranga Weerakkody's current disclosuresAt the time the article was last revised Bálint Botz had no recorded disclosures.
View Bálint Botz's current disclosures- Pulmonary manifestations of Hodgkin's disease
- Lung parenchymal involvement in Hodgkin disease
- Lung parenchymal involvement in Hodgkin lymphoma
Pulmonary manifestations of Hodgkin lymphoma are relatively rare, present in 5-12% of patients at the time of diagnosis. It is relatively more common with the nodular sclerosing subtype. Pulmonary involvement usually indicates stage IV disease.
Radiographic features
Bilateral involvement is seen in ~4% of cases 4.
Peribronchial infiltration may sometimes be seen 2. This may manifest as direct extension from hilar nodes, or as small peripheral nodules, which may or may not be cavitating. Other patterns include:
- masses
- mass-like consolidation
- diffuse interstitial thickening
Lung involvement without mediastinal nodal involvement is extremely rare in primary disease. In recurrent disease pulmonary parenchymal involvement is more common, and may occur without nodal enlargement 4.
References
- 1. Toma P, Granata C, Rossi A et-al. Multimodality imaging of Hodgkin disease and non-Hodgkin lymphomas in children. Radiographics. 27 (5): 1335-54. doi:10.1148/rg.275065157 - Pubmed citation
- 2. Macdonald JB. Lung involvement in Hodgkin's disease. Thorax. 1977;32 (6): 664-7. Thorax (link) - Free text at pubmed - Pubmed citation
- 3. Lewis ER, Caskey CI, Fishman EK. Lymphoma of the lung: CT findings in 31 patients. AJR Am J Roentgenol. 1991;156 (4): 711-4. AJR Am J Roentgenol (abstract) - Pubmed citation
- 4. Guermazi A, Brice P, De kerviler e E et-al. Extranodal Hodgkin disease: spectrum of disease. Radiographics. 21 (1): 161-79. Radiographics (full text) - Pubmed citation
Incoming Links
Related articles: Lymphoma
- overview of lymphoma
-
WHO classification of tumors of hematopoietic and lymphoid tissues
-
Hodgkin lymphoma
- Reed-Sternberg cells
- systemic involvement
- abdominal manifestations
- cardiac manifestations
- CNS manifestations
- musculoskeletal manifestations
- pulmonary manifestations
- non-Hodgkin lymphoma[+][+]
-
Hodgkin lymphoma
- location-specific lymphomas[+][+]
- central nervous system
- head and neck lymphoma
- thoracic lymphoma
- gastrointestinal lymphoma
- hepatobiliary lymphoma
- genitourinary lymphoma
- musculoskeletal lymphoma
- cutaneous lymphoma
- multi-regional
- lymphoma staging[+][+]