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WHO classification of haematolymphoid tumours

Changed by Francis Deng, 19 Feb 2019

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~~2008~~ WHO classification of tumours of haematopoietic and lymphoid tissues

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The ~~2008 WHO~~ World Health Organization (WHO) classification of ~~tumours~~tumors of ~~haematopoietic~~hematopoietic and lymphoid tissues is ~~at the time of writing (mid 2016)~~ the most widely used pathologic classification system for hematolymphoid neoplasms. The current revision, known as the 4th revised edition, was published in 2016, supersedes the 4th edition published in 2008, and is reflected in the article below ^1,^2,3.

Classification

Myeloid neoplasms

myeloproliferative neoplasms
- ~~nodular lymphocyte predominance~~chronic myeloid leukemia, BCR-ABL1-positive
- ~~classical Hodgkin lymphoma~~chronic neutrophilic leukemia
- polycythemia vera
- primary myelofibrosis
- essential thrombocythemia
- chronic eosinophilic leukemia, not otherwise specified
- myeloproliferative neoplasm, unclassifiable
mastocytosis
- ~~nodular sclerosing~~cutaneous mastocytosis
- systemic mastocytosis
  - indolent systemic mastocytosis
  - smoldering systemic mastocytosis
  - systemic mastocytosis with an associated hematological neoplasm
  - aggressive systemic mastocytosis
  - mast cell leukemia
- mast cell sarcoma
myeloid/lymphoid neoplasms with eosinophilia and gene rearrangement
- myeloid/lymphoid neoplasms with PDGFRA rearrangement
- myeloid/lymphoid neoplasms with PDGFRB rearrangement
- myeloid/lymphoid neoplasms with FGFR1 rearrangement
- myeloid/lymphoid neoplasms with PCM1-JAK2 (provisional entity)
myelodysplastic/myeloproliferative neoplasms
- chronic myelomonocytic leukemia
- atypical chronic myeloid leukemia, BCR-ABL1-negative
- juvenile myelomonocytic leukemia
- myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis
- myelodysplastic/myeloproliferative neoplasm, unclassifiable
myelodysplastic syndromes
- myelodysplastic syndrome with single lineage dysplasia
- myelodysplastic syndrome with multilineage dysplasia
- myelodysplastic syndrome with ring sideroblasts
  - myelodysplastic syndrome with ring sideroblasts and single lineage dysplasia
  - myelodysplastic syndrome with ring sideroblasts and multilineage dysplasia
- myelodysplastic syndrome with excess blasts
- myelodysplastic syndrome with isolated del(5q)
- myelodysplastic syndrome, unclassifiable
- refractory cytopenia of childhood (provisional entity)
myeloid neoplasms with germline predisposition
- myeloid neoplasms with germline predisposition without a preexisting disorder or organ dysfunction
  - acute myeloid leukemia with germline CEBPA mutation
  - myeloid neoplasms with germline DDX41 mutation
- myeloid neoplasms with germline predisposition and preexisting platelet disorders
  - myeloid neoplasms with germline RUNX1 mutation
  - myeloid neoplasms with germline ANKRD26 mutation
  - myeloid neoplasms with germline ETV6 mutation
- myeloid neoplasms with germline predisposition and other organ dysfunction
  - myeloid neoplasms with germline GATA2 mutation
  - myeloid neoplasms associated with bone marrow failure syndromes
  - myeloid neoplasms associated with telomere biology disorders
  - juvenile myelomonocytic leukemia associated with neurofibromatosis, Noonan syndrome or Noonan syndrome-like disorders
  - myeloid neoplasms associated with Down syndrome
acute myeloid leukemia and related neoplasms
- acute myeloid leukemia with recurrent genetic abnormalities
  - acute myeloid leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1
  - acute myeloid leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11
  - acute promyelocytic leukemia with PML-RARA
  - acute myeloid leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A
  - acute myeloid leukemia with t(6;9)(p23;q34.1); DEK-NUP214
  - acute myeloid leukemia with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2); GATA2, MECOM
  - acute myeloid leukemia (megakaryoblastic) with t(1;22)(p13.3;q13.3); RBM15-MKL1
  - acute myeloid leukemia with BCR-ABL1 (provisional entity)
  - acute myeloid leukemia with mutated NPM1
  - acute myeloid leukemia with biallelic mutations of CEBPA
  - acute myeloid leukemia with mutated RUNX1 (provisional entity)
- acute myeloid leukemia with myelodysplasia-related changes
- therapy-related myeloid neoplasms
- acute myeloid leukemia, not otherwise specified
  - acute myeloid leukemia with minimal differentiation
  - acute myeloid leukemia without maturation
  - acute myeloid leukemia with maturation
  - acute myelomonocytic leukemia
  - acute monoblastic/monocytic leukemia
  - pure erythroid leukemia
  - acute megakaryoblastic leukemia
  - acute basophilic leukemia
  - acute panmyelosis with myelofibrosis
- myeloid sarcoma
- myeloid proliferations related to Down syndrome
  - transient abnormal myelopoiesis
  - myeloid leukemia associated with Down syndrome
blastic plasmacytoid dendritic cell neoplasm
acute leukemias of ambiguous lineage
- acute undifferentiated leukemia
- mixed ~~cellularity~~phenotype acute leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1
- ~~lymphocyte rich~~mixed phenotype acute leukemia with t(v;11q23.3); KMT2A rearranged
- ~~lymphocyte depleted~~mixed phenotype acute leukemia, B/myeloid, not otherwise specified
- mixed phenotype acute leukemia, T/myeloid, not otherwise specified

Lymphoid neoplasms

precursor lymphoid neoplasms
- B-lymphoblastic leukemia/lymphoma
  - B-lymphoblastic leukemia/lymphoma, not otherwise specified
  - B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormalities
    - B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2); BCR-ABL1
    - B-lymphoblastic leukemia/lymphoma with t(v;11q23.3); KMT2A rearranged
    - B-lymphoblastic leukemia/lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1
    - B-lymphoblastic leukemia/lymphoma with hyperdiploidy
    - B-lymphoblastic leukemia/lymphoma with hypodiploidy
    - B-lymphoblastic leukemia/lymphoma with t(5;14)(q31.1;q32.3); IL3-IGH
    - B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3); TCF3-PBX1
    - B-lymphoblastic leukemia/lymphoma, BCR-ABL1–like (provisional entity)
    - B-lymphoblastic leukemia/lymphoma with iAMP21 (provisional entity)
- T-lymphoblastic leukemia/lymphoma
  - early T-cell precursor lymphoblastic leukemia (provisional entity)
- natural killer (NK) cell lymphoblastic leukemia/lymphoma (provisional entity)
mature B-cell neoplasms
- ~~precursor B-cell neoplasm~~
  - chronic lymphocytic ~~leukaemia~~leukemia/small lymphocytic lymphoma
  - monoclonal B-cell ~~prolymphoblastic leukaemia~~lymphocytosis
  - B-cell prolymphocytic leukemia
  - splenic marginal zone lymphoma
  - hairy cell ~~leukaemia~~leukemia
  - splenic B-cell lymphoma/leukemia, unclassifiable
    - splenic diffuse red pulp small B-cell lymphoma (provisional entity)
    - hairy cell leukemia-variant (provisional entity)
  - lymphoplasmacytic lymphoma
    - Waldenström macroglobulinemia
  - IgM monoclonal gammopathy of undetermined significance
  - heavy-chain diseases
    - μ heavy-chain disease
    - γ heavy-chain disease
    - α heavy-chain disease
  - plasma cell neoplasms
    - non-IgM monoclonal gammopathy of undetermined significance (IgG/A)
    - plasma cell myeloma/
    - plasma cell myeloma variants
      - smoldering (asymptomatic) plasma cell myeloma
      - non-secretory myeloma
      - plasma cell leukemia
    - plasmacytoma
      - solitary plasmacytoma of bone
      - extraosseous plasmacytoma
    - monoclonal immunoglobulin deposition diseases
      - primary amyloidosis
      - ~~lymphoplasmacytic lymphoma~~light chain and heavy chain deposition diseases
    - plasma cell neoplasms with associated paraneoplastic syndrome
      - POEMS syndrome
      - TEMPI syndrome
  - extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)
  - nodal marginal zone lymphoma
    - pediatric nodal marginal zone lymphoma (provisional entity)
  - follicular lymphoma
    - testicular follicular lymphoma
    - in situ follicular neoplasia
    - duodenal-type follicular lymphoma
  - pediatric-type follicular lymphoma
  - large B-cell lymphoma with IRF4 rearrangement (provisional entity)
  - primary cutaneous follicle center lymphoma
  - mantle cell lymphoma
    - leukemic non-nodal mantle cell lymphoma
    - in situ mantle cell neoplasia
  - diffuse large B-cell lymphoma, not otherwise specified
    - germinal center B-cell type
    - activated B-cell type
  - T-cell/histiocyte-rich large B-cell lymphoma
  - primary diffuse large B-cell lymphoma of the central nervous system
  - primary cutaneous diffuse large B-cell lymphoma, leg type
  - EBV-positive diffuse large B-cell lymphoma, not otherwise specified
  - EBV-positive mucocutaneous ulcer (provisional entity)
  - diffuse large B-cell lymphoma associated with chronic inflammation
    - fibrin-associated diffuse large B-cell lymphoma
  - primary mediastinal (thymic) large B-cell lymphoma
  - intravascular large B-cell lymphoma
  - ALK-positive large B-cell lymphoma
  - plasmablastic lymphoma
  - primary effusion lymphoma
  - ~~splenic marginal zone~~HHV8-associated lymphoproliferative disorders
    - multicentric Castleman disease
    - HHV8-positive diffuse large B-cell lymphoma
    , not otherwise specified (provisional entity)
  - HHV8-positive germinotropic lymphoproliferative disorder
- Burkitt lymphoma
- Burkitt-like lymphoma with 11q aberration (provisional entity)
B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma

mature T~~-cell~~- and NK-cell neoplasms

~~precursor T-cell neoplasm~~
- ~~precursor T-lymphoblastic leukaemia/lymphoma~~
~~mature (peripheral) T-cell neoplasms~~
- ~~T-cell prolymphoblastic leukaemia~~ / T-cell prolymphocytic ~~leukaemia~~leukemia
- T-cell large granular lymphocytic ~~leukaemia~~leukemia
- chronic lymphoproliferative disorder of NK cells (provisional entity)
- aggressive NK-cell ~~leukaemia~~leukemia
- EBV-positive T-cell and NK-cell lymphoproliferative diseases of childhood
  - systemic EBV-positive T-cell ~~lymphoproliferative disease~~lymphoma of childhood
  - chronic active EBV infection of T- and NK-cell type, systemic form
  - hydroa vacciniforme~~-like lymphoma~~ –like lymphoproliferative disorder
  - severe mosquito bite allergy
- adult T-cell ~~lymphoma/leukaemia~~leukemia/lymphoma
- extranodal NK-/T-cell lymphoma ~~(nasal~~, nasal type)
- ~~enteropathy associated~~intestinal T-cell lymphoma
  - enteropathy-associated T-cell lymphoma
  - monomorphic epitheliotropic intestinal T-cell lymphoma
  - intestinal T-cell lymphoma, not otherwise specified
  - indolent T-cell lymphoproliferative disorder of the gastrointestinal tract (provisional entity)
- hepatosplenic T-cell lymphoma
- subcutaneous panniculitis-like T-cell lymphoma
- mycosis fungoides
- Sézary syndrome
- ~~peripheral~~primary cutaneous CD30+ T-cell ~~lymphoma~~lymphoproliferative disorders
  - lymphomatoid papulosis
  - primary cutaneous anaplastic large cell lymphoma
- primary cutanoue peripheral T-cell lymphomas, rare subtypes
  - primary cutaneous γδ T-cell lymphoma
  - primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma (provisional entity)
  - primary cutaneous acral CD8+ T-cell lymphoma (provisional entity)
  - primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder (provisional entity)
- peripheral T-cell lymphoma, not otherwise specified
- angioimmunoblastic T-cell lymphoma and other nodal lymphomas of T follicular helper cell origin
  - angioimmunoblastic T-cell lymphoma
  - ~~mycosis fungoides~~follicular T-cell lymphoma (provisional entity)
  - nodal peripheral T-cell lymphoma with T follicular helperphenotype (provisional entity)
- anaplastic large-cell lymphoma, ALK-positive
- anaplastic large-cell lymphoma, ALK-negative
- breast implant-associated anaplastic large-cell lymphoma (provisional entity)
Hodgkin lymphoma
- nodular lymphocyte predominant Hodgkin lymphoma
- classical Hodgkin lymphoma
  - nodular sclerosis classical Hodgkin lymphoma
  - lymphocyte-rich classical Hodgkin lymphoma
  - mixed cellularity classical Hodgkin lymphoma
  - lymphocyte-depleted classical Hodgkin lymphoma
~~histiocytic~~posttransplant lymphoproliferative disorders (PTLD)
- plasmacytic hyperplasia PTLD
- infectious mononucleosis PTLD
- florid follicular hyperplasia PTLD
- polymorphic PTLD
- monomorphic PTLD
  - monomorphic B-cell PTLD
  - monomorphic T/NK-cell PTLD
- classical Hodgkin lymphoma PTLD

Histiocytic and dendritic cell neoplasms

histiocytic sarcoma
tumors derived from Langerhans cells
- Langerhans cell histiocytosis
- Langerhans cell sarcoma
indeterminate dendritic cell tumor
interdigitating dendritic cell sarcoma
follicular dendritic cell sarcoma
- inflammatory pseudotumor-like follicular/fibroblastic dendritic cell sarcoma
fibroblastic reticular cell ~~tumour~~tumor
~~intermediate dendritic cell tumour~~
disseminated juvenile xanthogranuloma

Erdheim-Chester disease~~(PTLDs)~~
~~early lesions~~

~~plasmacytic hyperplasia~~

~~infectious mononucleosis–like PTLD~~

~~polymorphic PTLD~~

~~monomorphic PTLD (B- and T/NK-cell types)~~

~~classical Hodgkin lymphoma-type PTLD~~

-The 2008 WHO classification of tumours of haematopoietic and lymphoid tissues is at the time of writing (mid 2016) the most widely used classification system. <h4>Classification</h4><ul>
+The World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues is the most widely used pathologic classification system for hematolymphoid neoplasms. The current revision, known as the 4th revised edition, was published in 2016, supersedes the 4th edition published in 2008, and is reflected in the article below 1,2,3.<h4>Classification</h4><h5>Myeloid neoplasms</h5><ul>
~~-<a href="/articles/hodgkin-lymphoma">Hodgkin lymphoma</a><ul>~~
~~-<li>nodular lymphocyte predominance</li>~~
~~-<li>classical Hodgkin lymphoma<ul>~~
~~-<li>nodular sclerosing</li>~~
~~-<li>mixed cellularity</li>~~
~~-<li>lymphocyte rich</li>~~
~~-<li>lymphocyte depleted</li>~~
+<a href="/articles/myeloproliferative-disorder">myeloproliferative neoplasms</a><ul>
+<li>
+<a href="/articles/chronic-myeloid-leukemia">chronic myeloid leukemia</a>, BCR-ABL1-positive</li>
+<li>chronic neutrophilic leukemia</li>
+<li><a href="/articles/polycythaemia-vera">polycythemia vera</a></li>
+<li><a href="/articles/myelofibrosis">primary myelofibrosis</a></li>
+<li><a href="/articles/essential-thrombocythemia">essential thrombocythemia</a></li>
+<li>chronic eosinophilic leukemia, not otherwise specified</li>
+<li>myeloproliferative neoplasm, unclassifiable</li>
+<li>
+<a href="/articles/mastocytosis">mastocytosis</a><ul>
+<li>cutaneous mastocytosis</li>
+<li>systemic mastocytosis<ul>
+<li>indolent systemic mastocytosis</li>
+<li>smoldering systemic mastocytosis</li>
+<li>systemic mastocytosis with an associated hematological neoplasm</li>
+<li>aggressive systemic mastocytosis</li>
+<li>mast cell leukemia</li>
~~-<li>mature B-cell neoplasms<ul>~~
~~-<li>precursor B-cell neoplasm<ul><li>~~
~~-<a href="/articles/precursor-b-lymphoblastic-leukaemia">precursor B-lymphoblastic leukaemia</a>/lymphoma</li></ul>~~
+<li>mast cell sarcoma</li>
+</ul>
+</li>
+<li>myeloid/lymphoid neoplasms with eosinophilia and gene rearrangement<ul>
+<li>myeloid/lymphoid neoplasms with PDGFRA rearrangement</li>
+<li>myeloid/lymphoid neoplasms with PDGFRB rearrangement</li>
+<li>myeloid/lymphoid neoplasms with FGFR1 rearrangement</li>
+<li>myeloid/lymphoid neoplasms with PCM1-JAK2 (provisional entity)</li>
+</ul>
+</li>
+<li>myelodysplastic/myeloproliferative neoplasms<ul>
+<li><a href="/articles/chronic-myelomonocytic-leukaemia">chronic myelomonocytic leukemia</a></li>
+<li>atypical chronic myeloid leukemia, BCR-ABL1-negative</li>
+<li>juvenile myelomonocytic leukemia</li>
+<li>myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis</li>
+<li>myelodysplastic/myeloproliferative neoplasm, unclassifiable</li>
+</ul>
~~-<li>mature (peripheral) B-cell neoplasms<ul>~~
~~-<li><a href="/articles/burkitt-lymphoma">Burkitt lymphoma</a></li>~~
~~-<a href="/articles/b-cell-chronic-lymphocytic-leukaemia">B-cell chronic lymphocytic leukaemia</a>/<a href="/articles/small-lymphocytic-lymphoma">small lymphocytic lymphoma</a>~~
+<a href="/articles/myelodysplastic-syndrome">myelodysplastic syndromes</a><ul>
+<li>myelodysplastic syndrome with single lineage dysplasia</li>
+<li>myelodysplastic syndrome with multilineage dysplasia</li>
+<li>myelodysplastic syndrome with ring sideroblasts<ul>
+<li>myelodysplastic syndrome with ring sideroblasts and single lineage dysplasia</li>
+<li>myelodysplastic syndrome with ring sideroblasts and multilineage dysplasia</li>
+</ul>
+</li>
+<li>myelodysplastic syndrome with excess blasts</li>
+<li>myelodysplastic syndrome with isolated del(5q)</li>
+<li>myelodysplastic syndrome, unclassifiable</li>
+<li>refractory cytopenia of childhood (provisional entity)</li>
+</ul>
+</li>
+<li>myeloid neoplasms with germline predisposition<ul>
+<li>myeloid neoplasms with germline predisposition without a preexisting disorder or organ dysfunction<ul>
+<li>acute myeloid leukemia with germline CEBPA mutation</li>
+<li>myeloid neoplasms with germline DDX41 mutation</li>
+</ul>
+</li>
+<li>myeloid neoplasms with germline predisposition and preexisting platelet disorders<ul>
+<li>myeloid neoplasms with germline RUNX1 mutation</li>
+<li>myeloid neoplasms with germline ANKRD26 mutation</li>
+<li>myeloid neoplasms with germline ETV6 mutation</li>
+</ul>
+</li>
+<li>myeloid neoplasms with germline predisposition and other organ dysfunction<ul>
+<li>myeloid neoplasms with germline GATA2 mutation</li>
+<li>myeloid neoplasms associated with bone marrow failure syndromes</li>
+<li>myeloid neoplasms associated with telomere biology disorders</li>
+<li>juvenile myelomonocytic leukemia associated with <a href="/articles/neurofibromatosis">neurofibromatosis</a>, <a href="/articles/noonan-syndrome">Noonan syndrome</a> or Noonan syndrome-like disorders</li>
+<li>myeloid neoplasms associated with <a href="/articles/down-syndrome">Down syndrome</a>
+</li>
+</ul>
+</li>
+</ul>
~~-<li><a href="/articles/b-cell-prolymphoblastic-leukaemia">B-cell prolymphoblastic leukaemia</a></li>~~
~~-<li><a href="/articles/hairy-cell-leukaemia">hairy cell leukaemia</a></li>~~
~~-<a href="/articles/plasma-cell-myeloma">plasma cell myeloma</a>/<a href="/articles/plasmacytoma">plasmacytoma</a>~~
+<a href="/articles/acute-myeloid-leukemia">acute myeloid leukemia</a> and related neoplasms<ul>
+<li>acute myeloid leukemia with recurrent genetic abnormalities<ul>
+<li>acute myeloid leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1
+</li>
+<li>acute myeloid leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11
~~-<li><a href="/articles/lymphoplasmacytic-lymphoma">lymphoplasmacytic lymphoma</a></li>~~
~~-<li><a href="/articles/follicular-lymphoma">follicular lymphoma</a></li>~~
~~-<li><a href="/articles/mantle-cell-lymphoma">mantle cell lymphoma</a></li>~~
~~-<a href="/articles/diffuse-large-b-cell-lymphoma">diffuse large B-cell lymphoma </a><ul>~~
~~-<li><a href="/articles/primary-mediastinal-large-b-cell-lymphoma">mediastinal large B-cell lymphoma</a></li>~~
~~-<li><a href="/articles/primary-effusion-lymphoma">primary effusion lymphoma</a></li>~~
~~-<li><a href="/articles/splenic-marginal-zone-b-cell-lymphoma">splenic marginal zone B-cell lymphoma</a></li>~~
+<a href="/articles/acute-promyelocytic-leukemia">acute promyelocytic leukemia</a> with PML-RARA
+</li>
+<li>acute myeloid leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A
+</li>
+<li>acute myeloid leukemia with t(6;9)(p23;q34.1); DEK-NUP214
+</li>
+<li>acute myeloid leukemia with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2); GATA2, MECOM
+</li>
+<li>acute myeloid leukemia (megakaryoblastic) with t(1;22)(p13.3;q13.3); RBM15-MKL1
+</li>
+<li>acute myeloid leukemia with BCR-ABL1 (provisional entity)</li>
+<li>acute myeloid leukemia with mutated NPM1
+</li>
+<li>acute myeloid leukemia with biallelic mutations of CEBPA
+</li>
+<li>acute myeloid leukemia with mutated RUNX1 (provisional entity)</li>
+</ul>
+</li>
+<li>acute myeloid leukemia with myelodysplasia-related changes</li>
+<li>therapy-related myeloid neoplasms</li>
+<li>acute myeloid leukemia, not otherwise specified<ul>
+<li>acute myeloid leukemia with minimal differentiation</li>
+<li>acute myeloid leukemia without maturation</li>
+<li>acute myeloid leukemia with maturation</li>
+<li>acute myelomonocytic leukemia</li>
+<li>acute monoblastic/monocytic leukemia</li>
+<li>pure erythroid leukemia</li>
+<li>acute megakaryoblastic leukemia</li>
+<li>acute basophilic leukemia</li>
+<li>acute panmyelosis with myelofibrosis</li>
+</ul>
+</li>
+<li><a href="/articles/myeloid-sarcoma-1">myeloid sarcoma</a></li>
+<li>myeloid proliferations related to Down syndrome<ul>
+<li>transient abnormal myelopoiesis</li>
+<li>myeloid leukemia associated with Down syndrome</li>
+</ul>
+</li>
+</ul>
+</li>
+<li><a href="/articles/blastic-plasmacytoid-dendritic-cell-neoplasm">blastic plasmacytoid dendritic cell neoplasm</a></li>
+<li>acute leukemias of ambiguous lineage<ul>
+<li>acute undifferentiated leukemia</li>
+<li>mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1
+</li>
+<li>mixed phenotype acute leukemia with t(v;11q23.3); KMT2A rearranged</li>
+<li>mixed phenotype acute leukemia, B/myeloid, not otherwise specified</li>
+<li>mixed phenotype acute leukemia, T/myeloid, not otherwise specified</li>
~~-<li><a href="/articles/solitary-bone-plasmacytoma-1">solitary plasmacytoma of bone </a></li>~~
~~-<li>extraosseous plasmacytoma</li>~~
~~-<li>primary cutaneous follicle centre lymphoma</li>~~
~~-<li>primary effusion lymphoma</li>~~
~~-<li><a href="/articles/nodal-marginal-zone-b-cell-lymphoma">nodal marginal zone B-cell lymphoma</a></li>~~
+</ul><h5>Lymphoid neoplasms</h5><ul>
~~-<a href="/articles/malt-lymphoma">extranodal marginal zone B-cell lymphoma</a> of MALT type</li>~~
+<a href="/articles/acute-lymphoblastic-leukaemia">precursor lymphoid neoplasms</a><ul>
+<li>B-lymphoblastic leukemia/lymphoma<ul>
+<li>B-lymphoblastic leukemia/lymphoma, not otherwise specified</li>
+<li>B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormalities<ul>
+<li>B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2); BCR-ABL1
+</li>
+<li>B-lymphoblastic leukemia/lymphoma with t(v;11q23.3); KMT2A rearranged</li>
+<li>B-lymphoblastic leukemia/lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1
+</li>
+<li>B-lymphoblastic leukemia/lymphoma with hyperdiploidy</li>
+<li>B-lymphoblastic leukemia/lymphoma with hypodiploidy</li>
+<li>B-lymphoblastic leukemia/lymphoma with t(5;14)(q31.1;q32.3); IL3-IGH
+</li>
+<li>B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3); TCF3-PBX1
+</li>
+<li>B-lymphoblastic leukemia/lymphoma, BCR-ABL1–like (provisional entity)</li>
+<li>B-lymphoblastic leukemia/lymphoma with iAMP21 (provisional entity)</li>
~~-<li>mature T-cell and NK-cell neoplasms<ul>~~
~~-<li>precursor T-cell neoplasm<ul><li>~~
~~-<a href="/articles/precursor-t-lymphoblastic-leukaemia">precursor T-lymphoblastic leukaemia</a>/lymphoma</li></ul>~~
+<li>T-lymphoblastic leukemia/lymphoma<ul><li>early T-cell precursor lymphoblastic leukemia (provisional entity)</li></ul>
~~-<li>mature (peripheral) T-cell neoplasms<ul>~~
+<li>natural killer (NK) cell lymphoblastic leukemia/lymphoma (provisional entity)</li>
+</ul>
+</li>
+<li>mature B-cell neoplasms<ul>
~~-<a href="/articles/t-cell-prolymphoblastic-leukaemia">T-cell prolymphoblastic leukaemia</a> / <a href="/articles/t-cell-prolymphocytic-leukaemia">T-cell prolymphocytic leukaemia</a>~~
+<a href="/articles/chronic-lymphocytic-leukaemia">chronic lymphocytic leukemia</a>/<a href="/articles/small-lymphocytic-lymphoma">small lymphocytic lymphoma</a>
~~-<li><a href="/articles/t-cell-granular-lymphocytic-leukaemia">T-cell large granular lymphocytic leukaemia</a></li>~~
~~-<li><a href="/articles/aggressive-nk-cell-leukaemia">aggressive NK-cell leukaemia</a></li>~~
~~-<li>systemic EBV-positive T-cell lymphoproliferative disease of childhood</li>~~
~~-<li>hydroa vacciniforme-like lymphoma </li>~~
+<li>monoclonal B-cell lymphocytosis</li>
+<li>B-cell prolymphocytic leukemia</li>
+<li>splenic marginal zone lymphoma</li>
+<li>hairy cell leukemia</li>
~~-<a href="/articles/adult-t-cell-lymphoma">adult T-cell lymphoma</a>/leukaemia</li>~~
+<a href="/articles/splenic-lymphoma">splenic B-cell lymphoma/leukemia, unclassifiable</a><ul>
+<li>splenic diffuse red pulp small B-cell lymphoma (provisional entity)</li>
+<li>hairy cell leukemia-variant (provisional entity)</li>
+</ul>
+</li>
+<li>lymphoplasmacytic lymphoma<ul><li><a href="/articles/waldenstrom-macroglobulinaemia">Waldenström macroglobulinemia</a></li></ul>
+</li>
+<li>IgM <a href="/articles/monoclonal-gammopathy-of-undetermined-significance">monoclonal gammopathy of undetermined significance</a>
+</li>
+<li>heavy-chain diseases<ul>
+<li>μ heavy-chain disease</li>
+<li>γ heavy-chain disease</li>
+<li>α heavy-chain disease</li>
+</ul>
+</li>
+<li>plasma cell neoplasms<ul>
+<li>non-IgM <a href="/articles/monoclonal-gammopathy-of-undetermined-significance">monoclonal gammopathy of undetermined significance</a> (IgG/A)</li>
+<li><a href="/articles/solitary-plasmacytoma-with-minimal-bone-marrow-involvement">plasma cell myeloma</a></li>
+<li>plasma cell myeloma variants<ul>
+<li><a href="/articles/smouldering-multiple-myeloma">smoldering (asymptomatic) plasma cell myeloma</a></li>
+<li>non-secretory myeloma</li>
+<li>plasma cell leukemia</li>
+</ul>
+</li>
~~-<a href="/articles/extranodal-nk-t-cell-lymphoma">extranodal NK/T-cell lymphoma</a> (nasal type)</li>~~
~~-<li><a href="/articles/enteropathy-type-t-cell-lymphoma">enteropathy associated T-cell lymphoma</a></li>~~
~~-<li><a href="/articles/hepatosplenic-t-cell-lymphoma">hepatosplenic T-cell lymphoma</a></li>~~
~~-<li><a href="/articles/subcutaneous-panniculitis-like-t-cell-lymphoma">subcutaneous panniculitis-like T-cell lymphoma</a></li>~~
~~-<li><a href="/articles/peripheral-t-cell-lymphoma">peripheral T-cell lymphoma</a></li>~~
~~-<li><a href="/articles/anaplasic-large-cell-lymphoma">anaplastic large cell lymphoma</a></li>~~
~~-<li><a href="/articles/angioimmunoblastic-t-cell-lymphoma">angioimmunoblastic T-cell lymphoma</a></li>~~
~~-<li><a href="/articles/mycosis-fungoides">mycosis fungoides</a></li>~~
+<a href="/articles/plasmacytoma">plasmacytoma</a><ul>
+<li><a href="/articles/solitary-bone-plasmacytoma-1">solitary plasmacytoma of bone</a></li>
+<li><a href="/articles/extramedullary-plasmacytoma">extraosseous plasmacytoma</a></li>
+</ul>
+</li>
+<li>monoclonal immunoglobulin deposition diseases<ul>
+<li>primary <a href="/articles/amyloidosis">amyloidosis</a>
+</li>
+<li>light chain and heavy chain deposition diseases</li>
+</ul>
+</li>
+<li>plasma cell neoplasms with associated paraneoplastic syndrome<ul>
+<li><a href="/articles/poems-syndrome">POEMS syndrome</a></li>
+<li>TEMPI syndrome</li>
+</ul>
+</li>
+</ul>
+</li>
+<li><a href="/articles/malt-lymphoma">extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)</a></li>
+<li>nodal <a href="/articles/marginal-zone-lymphoma">marginal zone lymphoma</a><ul><li>pediatric nodal marginal zone lymphoma (provisional entity)</li></ul>
+</li>
+<li>
+<a href="/articles/follicular-lymphoma">follicular lymphoma</a><ul>
+<li>testicular follicular lymphoma</li>
+<li>in situ follicular neoplasia</li>
+<li>duodenal-type follicular lymphoma</li>
+</ul>
+</li>
+<li>pediatric-type follicular lymphoma</li>
+<li>large B-cell lymphoma with IRF4 rearrangement (provisional entity)</li>
+<li>primary cutaneous follicle center lymphoma</li>
~~-<a title="Sezary syndrome" href="/articles/sezary-syndrome">Sézary syndrome</a></li>~~
+<a href="/articles/mantle-cell-lymphoma">mantle cell lymphoma</a><ul>
+<li>leukemic non-nodal mantle cell lymphoma</li>
+<li>in situ mantle cell neoplasia</li>
+<li>diffuse large B-cell lymphoma, not otherwise specified<ul>
+<li>germinal center B-cell type</li>
+<li>activated B-cell type</li>
~~-<li>histiocytic and dendritic cell neoplasms<ul>~~
~~-<li><a href="/articles/histiocytic-sarcoma">histiocytic sarcoma</a></li>~~
~~-<li><a href="/articles/langerhans-cell-histiocytosis">Langerhans cell histiocytosis</a></li>~~
~~-<li><a href="/articles/langerhans-cell-sarcoma">Langerhans cell sarcoma</a></li>~~
~~-<li><a href="/articles/interdigitating-dendritic-cell-sarcoma">interdigitating dendritic cell sarcoma</a></li>~~
~~-<li><a href="/articles/follicular-dendritic-cell-sarcoma">follicular dendritic cell sarcoma</a></li>~~
~~-<li><a href="/articles/fibroblastic-reticular-cell-tumour">fibroblastic reticular cell tumour</a></li>~~
~~-<li><a href="/articles/intermediate-dendritic-cell-tumour">intermediate dendritic cell tumour</a></li>~~
~~-<li><a href="/articles/disseminated-juvenile-xanthogranuloma">disseminated juvenile xanthogranuloma</a></li>~~
+<li>T-cell/histiocyte-rich large B-cell lymphoma</li>
+<li><a href="/articles/primary-cns-lymphoma">primary diffuse large B-cell lymphoma of the central nervous system</a></li>
+<li>primary cutaneous diffuse large B-cell lymphoma, leg type</li>
+<li><a href="/articles/ebv-positive-diffuse-large-b-cell-lymphoma-nos">EBV-positive diffuse large B-cell lymphoma, not otherwise specified</a></li>
+<li>EBV-positive mucocutaneous ulcer (provisional entity)</li>
+<li>diffuse large B-cell lymphoma associated with chronic inflammation<ul><li>fibrin-associated diffuse large B-cell lymphoma</li></ul>
+</li>
+<li>lymphomatoid granulomatosis</li>
+<li><a href="/articles/primary-mediastinal-large-b-cell-lymphoma">primary mediastinal (thymic) large B-cell lymphoma</a></li>
+<li>intravascular large B-cell lymphoma</li>
+<li>ALK-positive large B-cell lymphoma</li>
+<li>plasmablastic lymphoma</li>
+<li><a href="/articles/primary-effusion-lymphoma">primary effusion lymphoma</a></li>
+<li>HHV8-associated lymphoproliferative disorders<ul>
+<li>multicentric <a href="/articles/castleman-disease">Castleman disease</a>
+</li>
+<li>HHV8-positive diffuse large B-cell lymphoma, not otherwise specified (provisional entity)</li>
+<li>HHV8-positive germinotropic lymphoproliferative disorder</li>
+</ul>
+</li>
+<li><a href="/articles/burkitt-lymphoma">Burkitt lymphoma</a></li>
+<li>Burkitt-like lymphoma with 11q aberration (provisional entity)</li>
+<li>high-grade B-cell lymphoma<ul>
+<li>high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements</li>
+<li>high-grade B-cell lymphoma, not otherwise specified</li>
+</ul>
+</li>
+<li>B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma</li>
+</ul>
+</li>
+<li>mature T- and NK-cell neoplasms<ul>
+<li><a href="/articles/t-cell-prolymphocytic-leukaemia-1">T-cell prolymphocytic leukemia</a></li>
+<li>T-cell large granular lymphocytic leukemia</li>
+<li>chronic lymphoproliferative disorder of NK cells (provisional entity)</li>
+<li>aggressive NK-cell leukemia</li>
+<li>EBV-positive T-cell and NK-cell lymphoproliferative diseases of childhood<ul>
+<li>systemic EBV-positive T-cell lymphoma of childhood</li>
+<li>chronic active EBV infection of T- and NK-cell type, systemic form</li>
+<li>hydroa vacciniforme–like lymphoproliferative disorder</li>
+<li>severe mosquito bite allergy</li>
+<li>adult T-cell leukemia/lymphoma</li>
+<li>extranodal NK-/T-cell lymphoma, nasal type</li>
+<li>intestinal T-cell lymphoma<ul>
+<li>enteropathy-associated T-cell lymphoma</li>
+<li>monomorphic epitheliotropic intestinal T-cell lymphoma</li>
+<li>intestinal T-cell lymphoma, not otherwise specified</li>
+<li>indolent T-cell lymphoproliferative disorder of the gastrointestinal tract (provisional entity)</li>
+</ul>
+</li>
+<li>hepatosplenic T-cell lymphoma</li>
+<li>subcutaneous panniculitis-like T-cell lymphoma</li>
~~-<a href="/articles/post-transplant-lymphoproliferative-lymphoproliferation-disorder-ptld">post-transplantation lymphoproliferative disorders </a>(PTLDs)<ul>~~
~~-<li>early lesions<ul>~~
~~-<li>plasmacytic hyperplasia</li>~~
~~-<li>infectious mononucleosis–like PTLD</li>~~
+<a href="/articles/mycosis-fungoides">mycosis </a><a href="/articles/mycosis-fungoides">fungoides</a>
+</li>
+<li><a href="/articles/sezary-syndrome">Sézary syndrome</a></li>
+<li>primary cutaneous CD30+ T-cell lymphoproliferative disorders<ul>
+<li>lymphomatoid papulosis</li>
+<li>primary cutaneous anaplastic large cell lymphoma</li>
+<li>primary cutanoue peripheral T-cell lymphomas, rare subtypes<ul>
+<li>primary cutaneous γδ T-cell lymphoma</li>
+<li>primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma (provisional entity)</li>
+<li>primary cutaneous acral CD8+ T-cell lymphoma (provisional entity)</li>
+<li>primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder (provisional entity)</li>
+</ul>
+</li>
+<li>peripheral T-cell lymphoma, not otherwise specified</li>
+<li>angioimmunoblastic T-cell lymphoma and other nodal lymphomas of T follicular helper cell origin<ul>
+<li><a href="/articles/angioimmunoblastic-t-cell-lymphoma">angioimmunoblastic T-cell lymphoma</a></li>
+<li>follicular T-cell lymphoma (provisional entity)</li>
+<li>nodal peripheral T-cell lymphoma with T follicular helper phenotype (provisional entity)</li>
+</ul>
+</li>
+<li>anaplastic large-cell lymphoma, ALK-positive</li>
+<li>anaplastic large-cell lymphoma, ALK-negative</li>
+<li>
+<a href="/articles/breast-implant-associated-anaplastic-large-cell-lymphoma">breast implant-associated anaplastic large-cell lymphoma</a> (provisional entity)</li>
+</ul>
+</li>
+<li>
+<a href="/articles/hodgkin-lymphoma">Hodgkin lymphoma</a><ul>
+<li>nodular lymphocyte predominant Hodgkin lymphoma</li>
+<li>classical Hodgkin lymphoma<ul>
+<li>nodular sclerosis classical Hodgkin lymphoma</li>
+<li>lymphocyte-rich classical Hodgkin lymphoma</li>
+<li>mixed cellularity classical Hodgkin lymphoma</li>
+<li>lymphocyte-depleted classical Hodgkin lymphoma</li>
+</ul>
+</li>
+</ul>
+</li>
+<li>
+<a href="/articles/posttransplant-lymphoproliferative-disorder">posttransplant lymphoproliferative disorders</a> (PTLD)<ul>
+<li>plasmacytic hyperplasia PTLD</li>
+<li>infectious mononucleosis PTLD</li>
+<li>florid follicular hyperplasia PTLD</li>
~~-<li>monomorphic PTLD (B- and T/NK-cell types)</li>~~
~~-<li>classical Hodgkin lymphoma-type PTLD</li>~~
+<li>monomorphic PTLD<ul>
+<li>monomorphic B-cell PTLD</li>
+<li>monomorphic T/NK-cell PTLD</li>
+</ul>
+</li>
+<li>classical Hodgkin lymphoma PTLD</li>
+</ul>
+</li>
+</ul><h5>Histiocytic and dendritic cell neoplasms</h5><ul>
+<li><a href="/articles/histiocytic-sarcoma">histiocytic sarcoma</a></li>
+<li>tumors derived from Langerhans cells<ul>
+<li><a href="/articles/langerhans-cell-histiocytosis">Langerhans cell histiocytosis</a></li>
+<li>Langerhans cell sarcoma</li>
~~-</ul><h4>See also</h4><ul><li><a href="/articles/lymphoma">lymphoma (general)</a></li></ul>~~
+<li>indeterminate dendritic cell tumor</li>
+<li>interdigitating dendritic cell sarcoma</li>
+<li>follicular dendritic cell sarcoma<ul><li>inflammatory pseudotumor-like follicular/fibroblastic dendritic cell sarcoma</li></ul>
+</li>
+<li>fibroblastic reticular cell tumor</li>
+<li>disseminated juvenile xanthogranuloma</li>
+<li><a href="/articles/erdheim-chester-disease">Erdheim-Chester disease</a></li>
+</ul><h4>See also</h4><ul>
+<li><a href="/articles/lymphoma">lymphoma (general)</a></li>
+<li><a href="/articles/2016-histiocyte-society-classification-of-histiocytoses">Histiocyte Society classification of histiocytoses</a></li>
+<li><a href="/articles/erdheim-chester-disease">non-Langerhans cell histiocytosis </a></li>
+</ul>

References changed:

1. WHO Classification of Tumours Editorial Board. Haematolymphoid tumours [Internet; beta version ahead of print]. Lyon (France): International Agency for Research on Cancer; 2022 [cited 12 Mar 2022]. (WHO classification of tumours series, 5th ed.; vol. 11). Available from: <a href="https://tumourclassification.iarc.who.int/chapters/63">https://tumourclassification.iarc.who.int/chapters/63</a>.
4. Campo E, Swerdlow SH, Harris NL et-al. The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications. Blood. 2011;117 (19): 5019-32. <a href="http://dx.doi.org/10.1182/blood-2011-01-293050">doi:10.1182/blood-2011-01-293050</a> - <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109529">Free text at pubmed</a> - <a href="http://www.ncbi.nlm.nih.gov/pubmed/21300984">Pubmed citation</a>
1. General Thoracic Surgery. Thomas W Shields (Editor), Joseph LoCicero (Editor), Carolyn E Reed (Editor), Richard H Feins (Editor). Lippincott Williams & Wilkins <a href="http://books.google.com/books?vid=ISBN0781779820">ISBN:0781779820</a> <a href="http://www.amazon.com/gp/product/0781779820?ie=UTF8&tag=radiopaediaor-20&linkCode=as2&camp=1789&creative=9325&creativeASIN=0781779820">(find it at amazon.com)</a>
2. Harris NL, Jaffe ES, Diebold J et-al. The World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues. Report of the Clinical Advisory Committee meeting, Airlie House, Virginia, November, 1997. Ann. Oncol. 1999;10 (12): 1419-32. <a href="http://annonc.oxfordjournals.org/content/10/12/1419.abstract">Ann. Oncol. (abstract)</a> [<a href="http://www.ncbi.nlm.nih.gov/pubmed/10643532">pubmed citation</a>]
3. Rubin's pathology. editors, Raphael Rubin, David S. Strayer; consulting editor, Emanuel Rubin; associate editors, Jay M. McDonald. [et al.]. Philadelphia : Wolters Kluwer/Lippincott Williams & Wilkins, c2008. <a href="http://books.google.com/books?vid=ISBN0781795168">ISBN:0781795168</a> <a href="http://www.amazon.com/gp/product/0781795168?ie=UTF8&tag=radiopaediaor-20&linkCode=as2&camp=1789&creative=9325&creativeASIN=0781795168">(find it at amazon.com)</a>

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World Health Organisation classification of ~~neoplastic diseases~~tumours of haematopoietic and lymphoid tissues

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~~WHO~~World Health Organization classification of ~~lymphomas~~tumors of hematopoietic and ~~leukaemias~~lymphoid tissues

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WHO classification of haematolymphoid tumours

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Myeloid neoplasms

Lymphoid neoplasms

Histiocytic and dendritic cell neoplasms

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