McCune-Albright syndrome

McCune-Albright syndrome (MAS) (also known as McCune-Albright-Sternberg syndrome) is a genetic disorder characterized by the association of:

Presentation is variable 1:

  • leg pain, limp, pathological fracture: ~ 75%
  • abnormal vaginal bleeding: ~25%
  • coast of Maine café au lait spots
    • predominantly on posterior trunk: ~40% (range 30-50%)
    • often ipsilateral to bone lesions
    • irregular borders
  • hypercortisolism (Cushing syndrome): ~7% 3

MAS results from a sporadically occurring somatic GNAS gene mutation 2

The condition is named after:

  • Fuller Albright (1900-1969), an American endocrinologist 
  • Donovan James McCune (1902-1976), an American pediatrician 
  • Carl Sternberg (1872-1935), an Austrian pathologist 

Role of imaging in MAS is predominantly to identify and define fibrous dysplasia (refer to the article for specific features). It is also complementary in identifying related endocrinological conditions.

Bone tumours

The differential diagnosis for bone tumors is dependent on the age of the patient, with a very different set of differentials for the pediatric patient.

Article information

rID: 6568
Section: Syndromes
Synonyms or Alternate Spellings:
  • McCune-Albright-Sternberg syndrome

ADVERTISEMENT: Supporters see fewers/no ads

Cases and figures

  • Case 1
    Drag here to reorder.
  • Case 2
    Drag here to reorder.
  • Case 3
    Drag here to reorder.
  • Case 4
    Drag here to reorder.
  • Case 5
    Drag here to reorder.
  • Updating… Please wait.

     Unable to process the form. Check for errors and try again.

     Thank you for updating your details.