Typically affects patients in their 30s to 60s with a male predilection 3, 4. They may account for as many as 12% of chondrosarcomas of bone 2.
Extraskeletal lesions tend to present with a palpable mass 3, 4.
They are the most common extraskeletal chondrosarcomas, typically occurring in the deep soft tissues of the extremities, with the thigh being most common.
Conventional intramedullary chondrosarcomas can often demonstrate some degree of myxoid degeneration, leading to difficulty in accurate diagnosis of this entity 2.
Extensive myxoid stroma accounts not only for its name but also its high water content. Histologically as well as on imaging, these tumours are difficult to distinguish from chordomas and accounting for its alternative name of chordoid chondrosarcoma.
Going along with its more aggressive clinical course, the lesion is predominantly lytic, with the high water content giving it high signal on T2 weighted images, thus mimicking chordomas on imaging also. Enhancement is usually present but mild.
- 1. Varma DG, Ayala AG, Carrasco CH et-al. Chondrosarcoma: MR imaging with pathologic correlation. Radiographics. 1992;12 (4): 687-704. Radiographics (abstract) - Pubmed citation4.
- 2. Murphey MD, Walker EA, Wilson AJ et-al. From the archives of the AFIP: imaging of primary chondrosarcoma: radiologic-pathologic correlation. Radiographics. 23 (5): 1245-78. doi:10.1148/rg.235035134 - Pubmed citation
- 3. Pearls and Pitfalls in Musculoskeletal Imaging: Variants and Other Difficult Diagnoses. Cambridge University Press. ISBN:0521196329. Read it at Google Books - Find it at Amazon
- 4. Brennan MF, Antonescu CR, Maki RG. Management of Soft Tissue Sarcoma. Springer New York. ISBN:B00AKIFN6S. Read it at Google Books - Find it at Amazon
The differential diagnosis for bone tumours is dependent on the age of the patient, with a very different set of differentials for the paediatric patient.
- bone-forming tumours
- cartilage-forming tumours
- chondromyxoid fibroma
- fibrous bone lesions
- bone marrow tumours
- other bone tumours or tumour-like lesions
- aneurysmal bone cyst
- benign fibrous histiocytoma
- giant cell tumour of bone
- Gorham massive osteolysis
- haemophilic pseudotumour
- intradiploic epidermoid cyst
- intraosseous lipoma
- musculoskeletal angiosarcoma
- musculoskeletal haemangiopericytoma
- primary intraosseous haemangioma
- simple bone cyst
- impending fracture risk