Beta catenin mutated hepatic adenoma

Beta catenin mutated hepatic adenomas are a genetic and pathologic subtype of hepatic adenoma. Their appearance and prognosis are different than other subtypes.

They are the least common subtype of hepatic adenoma (10-15%). They occur more frequently in men and are associated with male hormone administration, glycogen storage disease, and familial adenomatous polyposis (FAP).

May develop right upper quadrant pain from intratumoural haemorrhage.

The appearance of this subtype overlaps the appearance of other subtypes. No distinctive imaging features have yet been identified.

If imaging shows a hepatic adenoma, then patients usually stop hormones administration, and the lesions regress ref required.

If it does not regress, then one treatment pathway suggests:

  • ≥5 cm: resection (hepatic adenomas larger than 5 cm are at increased risk of haemorrhage)
  • <5 cm: biopsy

Tissue diagnosis then confirms or changes the adenoma subtype. If beta-catenin mutated pathologic subtype, then the risk of malignant transformation to hepatocellular carcinoma is higher than with other subtypes, and follow-up should be according to HCC guidelines.

Hepatobiliary pathology
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Article information

rID: 35199
Section: Pathology
Synonyms or Alternate Spellings:
  • Beta catenin mutated hepatic adenomas
  • Beta catenin mutated hepatocellular adenoma
  • Beta catenin mutated hepatocellular adenomas
  • Beta catenin-mutated hepatic adenoma

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