Adenomyomatosis of the gallbladder

Adenomyomatosis of the gallbladder is a hyperplastic cholecystosis of the gallbladder wall. It is a relatively common and benign cause of diffuse or focal gallbladder wall thickening, most easily seen on ultrasound and MRI. 

Adenomyomatosis is relatively common, found in ~9% of all cholecystectomy specimens 5. It is typically seen in patients in their 5th decade. The incidence increases with age, presumably the result of protracted inflammation (see below). There is a female predilection (M:F=1:3).

It is most often an incidental finding and usually requires no treatment. It may be found more often in chronically inflamed gallbladders (which are at higher risk for carcinoma), but it is not a premalignant lesion in itself 5.

Adenomyomatosis per se is usually asymptomatic. It is, however, frequently associated with chronic biliary inflammation, most commonly gallstones (25-75%), but also seen in cholesterolosis (33%) and pancreatitis 2.

Adenomyomatosis is one of the hyperplastic cholecystoses. There is hyperplasia of the wall with the formation of Rokitansky-Aschoff sinuses (intramural diverticula lined by mucosal epithelium) penetrating into the muscular wall of the gallbladder, with or without gallbladder wall thickening. Cholesterol accumulation in adenomyomatosis is intraluminal, as cholesterol crystals precipitate in the bile trapped in Rokitansky-Aschoff sinuses.

Three morphological types of adenomyomatosis are described:

  • fundal (localized)
  • segmental (annular)
  • generalized (diffuse)
  • mural thickening (diffuse, focal, annular)
  • comet-tail artefact: echogenic intramural foci from which emanate V-shaped comet tail reverberation artefacts are highly specific for adenomyomatosis, representing the unique acoustic signature of cholesterol crystals within the lumina of Rokitansky-Aschoff sinuses 4
  • abnormal gallbladder wall thickening and enhancement are common but non-specific CT features of adenomyomatosis
  • Rokitansky-Aschoff sinuses of sufficient size can be visualized; a CT rosary sign has been described, formed by enhancing epithelium within intramural diverticula surrounded by the relatively unenhanced hypertrophied gallbladder muscularis

MRCP is the technique usually employed for the gallbladder and biliary tree characterization. Imaging features include:

  • mural thickening
  • focal sessile mass
  • fluid-filled intramural diverticula
    • pearl necklace sign refers to the characteristically curvilinear arrangement of multiple rounded hyperintense intraluminal cavities visualized on T2-weighted MR imaging and MRCP 4
  • hourglass configuration in annular types

Metabolic characterization with FDG PET has been suggested as a useful adjunct in problematic cases 4, but there have also been cases with increased uptake in areas of adenomyomatosis, leading to false positive results 6

Cholecystectomy may be performed as a result of one or more of the following:

  • patient symptomatic with right upper quadrant pain (often due to gallstones)
  • appearances (especially when focal) may be difficult to distinguish from malignancy

General imaging differential considerations include:

Exclusion of gallbladder cancer may be most problematic in segmental and focal cases. Focal adenomyomatosis may appear as a discrete mass, known as an adenomyoma.

Gallbladder and biliary tract pathology
Ultrasound - general index
Share article

Article information

rID: 7056
Synonyms or Alternate Spellings:
  • Adenomyomatous hyperplasia of the gallbladder
  • Adenomyomatosis of gallbladder
  • Gallbladder adenomyomatosis
  • Adenomyomatosis involving the gallbladder
  • Gallbladder adenomyoma
  • Gallbladder adenomyotosis
  • Adenomyoma of the gallbladder

Support Radiopaedia and see fewer ads

Cases and figures

  • Figure 1: adenomyomatosis
    Drag here to reorder.
  • Case 1
    Drag here to reorder.
  • Figure 2: histology
    Drag here to reorder.
  • Case 2: fundal
    Drag here to reorder.
  • Case 3
    Drag here to reorder.
  • Case 4
    Drag here to reorder.
  • Case 5
    Drag here to reorder.
  • Case 6: with rosary sign
    Drag here to reorder.
  • Case 7
    Drag here to reorder.
  • Thick-slice proje...
    Case 8
    Drag here to reorder.
  • MRC
    Case 9
    Drag here to reorder.
  • Case 10
    Drag here to reorder.
  • Case 11: segmental adenomyomatosis
    Drag here to reorder.
  • Case 12
    Drag here to reorder.
  • Case 13: with comet tail artefact
    Drag here to reorder.
  • Case 14: fundal localized type
    Drag here to reorder.
  • Case 15
    Drag here to reorder.
  • Updating… Please wait.

     Unable to process the form. Check for errors and try again.

     Thank you for updating your details.