Pancreatic intraepithelial neoplasia
Citation, DOI, disclosures and article data
At the time the article was created Henry Knipe had no recorded disclosures.View Henry Knipe's current disclosures
At the time the article was last revised Jeremy Jones had no recorded disclosures.View Jeremy Jones's current disclosures
Pancreatic intraepithelial neoplasia (PanIN) is a precursor lesion to pancreatic ductal adenocarcinoma, but the frequency at which this transition occurs is unknown.
Increasing incidence with age 1. Risk factors:
- pancreatic lipomatosis 3
Mostly flat lesions (occasionally papillary), consisting of varying degrees of epithelial atypia and dysplasia. They are histologically classified as low-grade or high-grade.
More commonly located in the pancreatic head 1.
Most are <5 mm, although they may be in the 5-10 mm range.
May produce unifocal or multifocal lobulocentric pancreatic atrophy but a preoperative diagnosis of PanIN is extremely difficult as it is a microscopic lesion 2,4.