Pyramidal lobe of thyroid

Last revised by Henry Knipe on 15 Oct 2024

The pyramidal lobe of the thyroid, also known as Lalouette pyramid 5, is a normal anatomic variant representing a superior projection of thyroid parenchyma arising from the thyroid isthmus. 

A pyramidal lobe is present in ~20 (range 10-30%) of the population ref and is commonly seen on routine thyroid ultrasound 3.

The pyramidal lobe is seen as a third thyroid lobe and represents a persistent remnant of the thyroglossal duct. It usually arises from the right or left side of the isthmus extending in a cranial direction; pyramidal lobes arising directly from the midline of the isthmus are rare (~2%) 3.

A band of fibrous tissue may be present extending superiorly from the pyramidal lobe to the hyoid bone, sometimes with a skeletal muscle component, termed the levator glandulae thyroideae muscle 4.

The pathologies seen in the remainder of thyroid can also seen in the pyramidal lobe ref.

Cases and figures

  • Figure 1: diagram
  • Case 1
  • Case 2: pyramidal lobe on ultrasound
  • Case 3: pyramidal lobe on I-123 scan
  • Case 4
  • Case 5: graves disease with pyramidal lobe
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