Salt and pepper sign (Sjögren syndrome)
Citation, DOI, disclosures and article data
Citation:
Bell D, Niknejad M, Ranchod A, Salt and pepper sign (Sjögren syndrome). Reference article, Radiopaedia.org (Accessed on 24 Mar 2025) https://doi.org/10.53347/rID-95435
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rID:
95435
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Disclosures:
At the time the article was created Daniel J Bell had no recorded disclosures.
View Daniel J Bell's current disclosures
Last revised:
Disclosures:
At the time the article was last revised Mohammad Taghi Niknejad had no financial relationships to ineligible companies to disclose.
View Mohammad Taghi Niknejad's current disclosures
Revisions:
3 times, by
3 contributors -
see full revision history and disclosures
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Synonyms:
- Salt and pepper appearance (Sjögren syndrome)
- Salt and pepper appearance (Sjögren disease)
- Salt and pepper sign (Sjogren disease)
- Salt and pepper parotid appearance
The salt and pepper sign has been used to describe the MRI appearance of the parotid gland in Sjögren syndrome due to combination of punctate regions of calcification (pepper) and fatty replacement (salt) 1.
A similar appearance may be seen in HIV-associated salivary gland disease due to mixed solid and cystic lesions that enlarge the parotid glands 2.
References
- 1.Takashima S, Takeuchi N, Morimoto S et al. MR Imaging of Sjögren Syndrome: Correlation with Sialography and Pathology. J Comput Assist Tomogr. 1991;15(3):393-400. doi:10.1097/00004728-199105000-00009 - Pubmed
- 2. Ellis GL. Lymphoid lesions of salivary glands: malignant and benign. (2007) Medicina oral, patologia oral y cirugia bucal. 12 (7): E479-85. Pubmed
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