Zebra stripe sign (bones)

Last revised by Ashesh Ishwarlal Ranchod ◉ on 24 Nov 2024

Citation, DOI, disclosures and article data

Citation:

Sargent M, Ranchod A, Sharma R, et al. Zebra stripe sign (bones). Reference article, Radiopaedia.org (Accessed on 09 Mar 2025) https://doi.org/10.53347/rID-6038

DOI:

https://doi.org/10.53347/rID-6038

Permalink:

https://radiopaedia.org/articles/6038

rID:

6038

Article created:

10 Apr 2009, Michael Sargent

Disclosures:

At the time the article was created Michael Sargent had no recorded disclosures.

View Michael Sargent's current disclosures

Last revised:

24 Nov 2024, Ashesh Ishwarlal Ranchod ◉

Disclosures:

At the time the article was last revised Ashesh Ishwarlal Ranchod had no financial relationships to ineligible companies to disclose.

View Ashesh Ishwarlal Ranchod's current disclosures

Revisions:

17 times, by 14 contributors - see full revision history and disclosures

Systems:

Musculoskeletal, Paediatrics

Sections:

Signs

Tags:

refs

The zebra stripe sign occurs where children with osteogenesis imperfecta have been treated with cyclical bisphosphonate therapy, e.g. pamidronate disodium. When the drug is delivered in cycles, dense bone is formed while treatment is being given. This results in dense stripes across the metaphyses of bones which can be visualized radiographically.

This sign ¹ is not to be confused with the zebra sign ², which refers to remote cerebellar hemorrhage.