Pulmonary hamartomas are benign neoplasms composed of cartilage, connective tissue, muscle, fat, and bone. It is one of the most common benign tumours of the lung, and accounts for ~8% of all lung neoplasms and 6% of solitary pulmonary nodules.
Pulmonary chondroma has been used interchangeably with pulmonary hamartoma in the past but they should be considered separate entities due to histological differences 14.
Patients usually present in the 4th and 5th decades of life and they are very uncommon in children. There is a recognised male predilection ( M:F = 2.5:1). Most lesions are diagnosed incidentally.
Pulmonary hamartomas are usually asymptomatic and found incidentally when imaging the chest for other reasons. It can occasionally present with haemoptysis, bronchial obstruction and cough (especially endobronchial types) 6.
Hamartomas may be chondromatous (more common), leiomyomatous, or a mixture. They are unencapsulated, lobulated tumours with connective tissue septa.
As with any hamartoma it is composed of tissues that normally constitute in the lung and bronchi. The tissue elements, although mature, are disorganized. On rare occasion, they contain principally fatty tissue, in which case they are called lipomatous hamartomas or endobronchial lipomas.
The vast majority of pulmonary hamartomas are located peripherally within the lungs (> 90%), with endobronchial hamartomas representing only ~5% (range 1.4-10%) of such lesions 10-11.
Typically, hamartomas manifest incidentally as solitary nodules in the periphery of the lung.
Often discovered incidentally. They are typically well-circumscribed nodules or masses (usually small) with either smooth or lobulated margins. Approximately 60% have fat 7 and approximately 20-30% have calcification/ossification (popcorn-like) 3. Cavitation is not seen.
Size is variable, and they can be large (>10 cm) but in most cases they are <2.5-4 cm in diameter 10,13.
Growth occurs but is very slow, with a typical volume doubling time (VDT) of over 400 days 9.
Chest radiography is non-specific, demonstrating a soft tissue attenuation, well-circumscribed mass with either smooth or lobulated margins. Calcification (classically popcorn type) may be seen, which can suggest the diagnosis. Fat is difficult to identify with certainty, although the lesion is typically of low density for its size.
CT is far superior in detecting intralesional fat and calcification. The reported prevalence of calcification in hamartomas on CT varies from 5 to 50% while fat may be identified in up to 60% of hamartomas at CT. The fat compoments may be localized or generalized within the nodule.
Fat can be recognised by comparing it to subcutaneous fat, and will typically have a Hounsfield measurement of -40 to -120 HU 10. Presence of fat in a well circumscribed solitary pulmonary nodule which does not demonstrate significant growth is essentially pathognomonic of a pulmonary hamartoma and no further investigations are required 7. Unfortunately fat can only be identified in 60% of lesions. Thin section CT is therefore essential to avoid missing small foci of fat.
Calcification is typically dispersed in the form of multiple clumps throughout the lesion in a popcorn configuration 3.
Although uncommon, increased avidity may be seen on FDG-PET 7. Thus, further investigation with PET-CT of slow-growing, fat-containing masses is unwarranted, confusing, and contributes to patient radiation dose.
T1: heterogeneous signal
- mainly intermediate signal 8
- foci of high signal represent fat
- low signal regions representing fibrous or calcific material
- high signal due to fat and cartilaginous components
- low signal regions representing fibrous or calcific material
- T1 C+ (Gd): heterogeneous enhancement is seen
Treatment and prognosis
Malignant transformation is exceedingly rare, and a peripheral small hamartoma with no atypical features can be safely left alone, with infrequent follow-up to exclude growth.
In atypical cases, or in cases of endobronchial hamartomas causing distal complications, surgical resection is curative. Rigid transbronchial resection is most frequently employed in the later 12.
The differential is somewhat dependent on whether fat or calcification is identifiable within the lesion.
If fat is visualised then the differential is narrow, with almost all cases representing pulmonary hamartoma. See differential of fat containing solitary pulmonary nodule.
Presence of calcification also significantly narrows the differential, but to a lesser degree. See differential of a solitary pulmonary nodule with calcification.
If neither fat nor calcification is present, then the differential is that of a solitary pulmonary nodule and is significantly broader. See-differential of a solitary pulmonary nodule.
lung cancer: overview
non small-cell lung cancer
- adenosquamous carcinoma
- large cell carcinoma
- primary sarcomatoid carcinoma of lung
- squamous cell carcinoma
- salivary gland type tumours
- pulmonary neuroendocrine tumours
- preinvasive lesions
- benign neoplasms
- pulmonary metastases
- lung cancer screening
- lung cancer staging
- non small-cell lung cancer
- 1. Weissleder R, Wittenberg J, Harisinghani MG. Primer of diagnostic imaging. Mosby Inc. (2007) ISBN:0323040683. Read it at Google Books - Find it at Amazon
- 2. Brant WE, Helms CA. Fundamentals of diagnostic radiology. Lippincott Williams & Wilkins. (2007) ISBN:0781765188. Read it at Google Books - Find it at Amazon
- 3. Chai JL, Patz EF. CT of the lung: patterns of calcification and other high-attenuation abnormalities. AJR Am J Roentgenol. 1994;162 (5): 1063-6. AJR Am J Roentgenol (abstract) - Pubmed citation
- 4. Marchiori E, Souza AS, Franquet T et-al. Diffuse high-attenuation pulmonary abnormalities: a pattern-oriented diagnostic approach on high-resolution CT. AJR Am J Roentgenol. 2005;184 (1): 273-82. AJR Am J Roentgenol (full text) - Pubmed citation
- 5. Gaerte SC, Meyer CA, Winer-muram HT et-al. Fat-containing lesions of the chest. Radiographics. 2002;22 Spec No : S61-78. Radiographics (link) - Pubmed citation
- 6. Thomas JW, Staerkel GA, Whitman GJ. Pulmonary hamartoma. AJR Am J Roentgenol. 1999;172 (6): 1643. AJR Am J Roentgenol (citation) - Pubmed citation
- 7. Klein JS, Braff S. Imaging evaluation of the solitary pulmonary nodule. Clin. Chest Med. 2008;29 (1): 15-38, v. doi:10.1016/j.ccm.2007.11.007 - Pubmed citation
- 8. Kauczor H, Baert AL. MRI of the Lung. Springer Verlag. (2009) ISBN:354034618X. Read it at Google Books - Find it at Amazon
- 9. Naidich DP, Srichai MB, Krinsky GA. Computed tomography and magnetic resonance of the thorax. Lippincott Williams & Wilkins. (2007) ISBN:0781757657. Read it at Google Books - Find it at Amazon
- 10. Collins J, Stern EJ. Chest radiology, the essentials. Lippincott Williams & Wilkins. (2007) ISBN:0781763142. Read it at Google Books - Find it at Amazon
- 11. Cosío BG, Villena V, Echave-sustaeta J et-al. Endobronchial hamartoma. Chest. 2002;122 (1): 202-5. doi:10.1378/chest.122.1.202 - Pubmed citation
- 12. Ishibashi H, Akamatsu H, Kikuchi M et-al. Resection of endobronchial hamartoma by bronchoplasty and transbronchial endoscopic surgery. Ann. Thorac. Surg. 2003;75 (4): 1300-2. - Pubmed citation
- 13. Siegelman SS, Khouri NF, Scott WW et-al. Pulmonary hamartoma: CT findings. Radiology. 1986;160 (2): 313-7. Pubmed citation
- 14. Rodriguez FJ, Aubry MC, Tazelaar HD et-al. Pulmonary chondroma: a tumor associated with Carney triad and different from pulmonary hamartoma. Am. J. Surg. Pathol. 2007;31 (12): 1844-53. doi:10.1097/PAS.0b013e3180caa0b5 - Pubmed citation