WHO classification of tumors of soft tissue
Updates to Article Attributes
The World World Health Organisation (WHO) classification of soft tissue tumours is is the most widely used pathology-based classification system for such disorders. The current The revision, part of the 5th edition of the WHO classification of soft tissue and bone tumours (volume 3), was published in 2020 and is reflected in the article below 1.
Classification
Adipocytic tumours
lipoblastoma
andand lipoblastomatosis
Fibroblastic/myofibroblastic tumours
So-called fibrohistiocytic tumours
Vascular tumours
-
arteriovenous malformation/haemangioma
venous haemangioma
lymphangioma
andand lymphangiomatosistufted angioma and Kaposiform haemangioendothelioma
Pericytic (perivascular) tumours
myopericytoma, including myofibroma
Smooth muscle tumours
EBV-associated smooth muscle tumour
inflammatory leiomyosarcoma
Skeletal-muscle tumours
Gastrointestinal stromal tumours
Chondro-osseous tumours
Peripheral nerve sheath tumours
schwannoma (including variants)
neurofibroma (including variants)
Tumours of uncertain differentiation
myoepithelioma/myoepithelial carcinoma/mixed tumour
NTRK-rearranged soft tissue neoplasms
Changes from the prior version
New entitiesEntities and variants
Newly introduced entitiesEntities include the following 1-5:
-
adipocytic tumours
-
fibroblastic and myofibroblastic tumours
EWSR-SMAD3-positive fibroblastic tumour
-
vascular tumours
epithelioid haemangioendothelioma features two
newlyrecognised subtypestufted angioma and Kaposiform haemangioendothelioma are classified together
-
pericytic (perivascular) tumours
myopericytoma, including myofibroma -
newsubtype:cellularcellular myofibroma/myopericytoma
-
smooth muscle tumours
EBV-associated smooth muscle tumour
inflammatory leiomyosarcoma
-
skeletal muscle tumours
spindle cell/sclerosing rhabdomyosarcoma-
threethree subtypes
-
tumours of uncertain differentiation
NTRK-rearranged soft tissue neoplasms
Other changes
melanotic schwannoma: now renamed to malignant melanotic nerve sheath tumour
dedifferentiated liposarcoma: adverse prognostic impact of myogenic and rhabdomyoblastic differentiation as well of a high grade on the FNCLCC (French Federation of Cancer Centres Sarcoma Group) grading system
solitary fibrous tumour: 'extrapleural' has been removed
-<p>The<strong> World Health Organisation (WHO) classification of soft tissue tumours</strong> is the most widely used pathology-based classification system for such disorders. The current revision, part of the 5th edition of the WHO classification of soft tissue and bone tumours (volume 3), was published in 2020 and is reflected in the article below <sup>1</sup>.</p><h4>Classification</h4><h5>Adipocytic tumours</h5><ul>- +<p>The<strong> World Health Organisation (WHO) classification of soft tissue tumours</strong> is the most widely used pathology-based classification system for such disorders. The revision, part of the 5th edition of the WHO classification of soft tissue and bone tumours (volume 3), was published in 2020 and is reflected in the article below <sup>1</sup>.</p><h4>Classification</h4><h5>Adipocytic tumours</h5><ul>
-<li><p><a href="/articles/lipoblastoma">lipoblastoma</a> and <a href="/articles/lipoblastomatosis">lipoblastomatosis</a></p></li>- +<li><p><a href="/articles/lipoblastoma">lipoblastoma</a> and <a href="/articles/lipoblastomatosis">lipoblastomatosis</a></p></li>
-<li><p><a href="/articles/intramuscular-hemangiomas">intramuscular haemangioma</a></p></li>- +<li><p><a href="/articles/intramuscular-haemangiomas">intramuscular haemangioma</a></p></li>
-<li><p><a href="/articles/lymphatic-malformations-1">lymphangioma</a> and <a href="/articles/lymphangiomatosis">lymphangiomatosis</a></p></li>- +<li><p><a href="/articles/lymphatic-malformations-1">lymphangioma</a> and <a href="/articles/lymphangiomatosis">lymphangiomatosis</a></p></li>
-<li><p><a href="/articles/ectopic-meningioma">ectopic meningioma</a> and <a href="/articles/meningothelial-hamartoma">meningothelial hamartoma</a></p></li>- +<li><p><a href="/articles/ectopic-meningioma">ectopic meningioma</a> and <a href="/articles/meningothelial-hamartoma">meningothelial hamartoma</a></p></li>
-</ul><h4>Changes from the prior version</h4><h5>New entities and variants</h5><p>Newly introduced entities include the following <sup>1-5</sup>:</p><ul>- +</ul><h4>Changes from the prior version</h4><h5>Entities and variants</h5><p>Entities include the following <sup>1-5</sup>:</p><ul>
-<li><p><a href="/articles/epithelioid-haemangioendothelioma-2" title="Epithelioid haemangioendothelioma">epithelioid haemangioendothelioma</a> features two newly recognised subtypes</p></li>- +<li><p><a href="/articles/epithelioid-haemangioendothelioma-2" title="Epithelioid haemangioendothelioma">epithelioid haemangioendothelioma</a> features two recognised subtypes</p></li>
-<ul><li><p>myopericytoma, including myofibroma - new subtype: cellular myofibroma/myopericytoma</p></li></ul>- +<ul><li><p>myopericytoma, including myofibroma - subtype: cellular myofibroma/myopericytoma</p></li></ul>
-<ul><li><p><a href="/articles/spindle-cell-rhabdomyosarcoma">spindle cell/sclerosing rhabdomyosarcoma</a> - three subtypes</p></li></ul>- +<ul><li><p><a href="/articles/spindle-cell-rhabdomyosarcoma">spindle cell/sclerosing rhabdomyosarcoma</a> - three subtypes</p></li></ul>
References changed:
- 7. Ahlawat S & Fayad L. Revisiting the WHO Classification System of Soft Tissue Tumours: Emphasis on Advanced Magnetic Resonance Imaging Sequences. Part 1. Pol J Radiol. 2020;85:e396-408. <a href="https://doi.org/10.5114/pjr.2020.98685">doi:10.5114/pjr.2020.98685</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/32999693">Pubmed</a>
- 7. Ahlawat S & Fayad L. Revisiting the WHO Classification System of Soft Tissue Tumours: Emphasis on Advanced Magnetic Resonance Imaging Sequences. Part 1. Pol J Radiol. 2020;85(1):e396-408. <a href="https://doi.org/10.5114/pjr.2020.98685">doi:10.5114/pjr.2020.98685</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/32999693">Pubmed</a>