Acinar-predominant adenocarcinoma of the lung is a histological subtype of non-mucinous invasive adenocarcinoma of the lung.
In 2011, the International Association for the Study of Lung Cancer (IASLC), American Thoracic Society (ATS), and European Respiratory Society (ERS) 4 introduced a new classification and terminology for adenocarcinoma of the lung, which is now divided into 'preinvasive', 'minimally invasive', and 'invasive'.
The term bronchoalveolar carcinoma (BAC) has been retired, and it is recommended that all invasive adenocarcinomas be classified in terms of the "predominant" comprising histology 4. Both mucinous and non-mucinous adenocarcinomas typically consist of a mixture of histologic patterns, but reporting of the predominant subtype (lepidic, acinar, papillary, micropapillary, or solid growth) is specifically recommended for non-mucinous lesions, with all mucinous tumors placed in a separate category.
Treatment and prognosis
Acinar patterns are thought to have an intermediate prognosis but better than those associated with micropapillary, mucinous/colloid, and solid patterns and worse than those with lepidic predominant patterns 1,3.
- 1. Tang ER, Schreiner AM, Pua BB. Advances in lung adenocarcinoma classification: a summary of the new international multidisciplinary classification system (IASLC/ATS/ERS). (2014) Journal of thoracic disease. 6 (Suppl 5): S489-501. doi:10.3978/j.issn.2072-1439.2014.09.12 - Pubmed
- 2. Russell PA, Wright GM. Predominant histologic subtype in lung adenocarcinoma predicts benefit from adjuvant chemotherapy in completely resected patients: discovery of a holy grail?. (2016) Annals of translational medicine. 4 (1): 16. doi:10.3978/j.issn.2305-5839.2015.10.21 - Pubmed
- 3. Russell PA, Wainer Z, Wright GM, Daniels M, Conron M, Williams RA. Does lung adenocarcinoma subtype predict patient survival?: A clinicopathologic study based on the new International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international multidisciplinary lung adenocarcinoma classification. (2011) Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 6 (9): 1496-504. doi:10.1097/JTO.0b013e318221f701 - Pubmed
- 4. Travis WD, Brambilla E, Noguchi M et-al. International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol. 2011;6 (2): 244-85. doi:10.1097/JTO.0b013e318206a221 - Pubmed citation
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