Thallium-201 scintigraphy
Citation, DOI, disclosures and article data
Citation:
Lall N, Yap J, Bell D, et al. Thallium-201 scintigraphy. Reference article, Radiopaedia.org (Accessed on 23 Jan 2025) https://doi.org/10.53347/rID-24811
Permalink:
rID:
24811
Article created:
14 Sep 2013,
Neil Lall
Disclosures:
At the time the article was created Neil Lall had no recorded disclosures.
View Neil Lall's current disclosures
Last revised:
Disclosures:
At the time the article was last revised Joshua Yap had no financial relationships to ineligible companies to disclose.
View Joshua Yap's current disclosures
Revisions:
17 times, by
12 contributors -
see full revision history and disclosures
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Synonyms:
- Tl-201 chloride scintigraphy
- Thallium-201 chloride scintigraphy
- Thallous chloride scintigraphy
- Thallium scintigraphy
Thallium-201 (Tl-201) is a radiopharmaceutical used for scintigraphy, primarily of the myocardium. The element thallium is treated by the body as an analog of potassium; it is produced in a cyclotron by bombarding thallium-203 with protons.
Characteristics
- thallium is a monovalent cation
- usually employed in the form of a chloride salt
- photon energy: 68-80 keV (a smaller amount of γ-rays at 137 and 167 keV)
- physical half life: 73 hours
- biological half life
- rest: 3 minutes
- exercise: 30 seconds
- normal distribution: myocardium, skeletal muscle, GI tract, liver, kidneys
- excretion: renal
- target organ: kidneys
- miscellaneous facts:
- more background noise than MUGA
- thallium-201 cerebral SPECT can be used to differentiate toxoplasmosis vs lymphoma (increased uptake in lymphoma, decreased in toxoplasmosis)
Uses, doses and timings
Cardiac scan
References
- 1. Weissleder R, Wittenberg J, Harisinghani MMGH et-al. Primer of Diagnostic Imaging. Mosby. (2011) ISBN:0323065384. Read it at Google Books - Find it at Amazon
- 2. Blumenthal RS, Becker DM, Moy TF, Coresh J, Wilder LB, Becker LC. Exercise thallium tomography predicts future clinically manifest coronary heart disease in a high-risk asymptomatic population. (1996) Circulation. 93 (5): 915-23. doi:10.1161/01.cir.93.5.915 - Pubmed
- 3. Robert A. Pagnanelli, Danny A. Basso. Myocardial Perfusion Imaging with 201Tl. (2010) Journal of Nuclear Medicine Technology. 38 (1): 1. doi:10.2967/jnmt.109.068593 - Pubmed
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