Gd-DTPA labeled albumin
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At the time the article was created J. Ray Ballinger had no recorded disclosures.View J. Ray Ballinger's current disclosures
At the time the article was last revised Andrew Murphy had no recorded disclosures.View Andrew Murphy's current disclosures
Gd-DTPA labeled albumin is an intravascular MRI contrast agent. Gd-DTPA is covalently bonded to albumin in ratios from 16:1 to 31:1 providing excellent enhancement of liver, spleen, myocardium, brain, and slow moving blood of rats and rabbits. The albumin has a molecular weight of about 92,000 and a biological half-life of 88 minutes. The dose of Gd-DTPA required when bound to albumin is 0.062 mmol/kg compared to usual doses of the chelate alone of 0.1-0.2 mmol/kg. No adverse reactions are reported, but in vivo retention of the gadolinium for several weeks in liver and bone raises concerns of long term toxicity.
- Schmiedl U, Brasch RC, Ogan MD et-al. Albumin labeled with Gd-DTPA. An intravascular contrast-enhancing agent for magnetic resonance blood pool and perfusion imaging. Acta Radiol Suppl. 1992;374: 99-102. Pubmed citation
- Schmiedl U, Ogan M, Paajanen H et-al. Albumin labeled with Gd-DTPA as an intravascular, blood pool-enhancing agent for MR imaging: biodistribution and imaging studies. Radiology. 1987;162 (1 Pt 1): 205-10. Pubmed citation