Time to peak (TTP)
Citation, DOI, disclosures and article data
Citation:
Thapa G, Murphy A, Hacking C, et al. Time to peak (TTP). Reference article, Radiopaedia.org (Accessed on 21 Nov 2024) https://doi.org/10.53347/rID-69302
Permalink:
rID:
69302
Article created:
6 Jul 2019,
Gobardhan Thapa
Disclosures:
At the time the article was created Gobardhan Thapa had no recorded disclosures.
View Gobardhan Thapa's current disclosures
Last revised:
Disclosures:
At the time the article was last revised Andrew Murphy had no recorded disclosures.
View Andrew Murphy's current disclosures
Revisions:
6 times, by
4 contributors -
see full revision history and disclosures
Systems:
Sections:
Synonyms:
- Time-to-peak
- Time to peak (TTP)
Time-to-peak (TTP) is the time at which contrast concentration reaches its maximum. For example, for a particular dynamic susceptibility contrast (DSC) imaging acquisition in which images are acquired every 1.5 seconds, possible TTP values could include 20.0 seconds, 21.5 seconds, 23.0 seconds, etc.
The advantages of TTP in this role are:
- defects on TTP maps are conspicuous and usually well-defined
- TTP is a reproducible technique, in that measurements obtained by different centers from a single data set are similar, with less technique-dependent artifacts to complicate interpretation
TTP is very sensitive to motion artifacts and noise, so some algorithms that perform motion correction and pre-filtering will produce differing results. Some algorithms also perform curve fitting to obtain TTP.
The primary disadvantage of using TTP is that TTP can be prolonged in a wide variety of acute and chronic hemodynamic conditions. TTP prolongation may be caused by reduced blood flow, but also occurs when the arrival of the injected contrast bolus is delayed, but cerebral blood flow (CBF) is normal.
References
- 1. Aaron R. Hochberg, Geoffrey S. Young. Cerebral Perfusion Imaging. (2012) Seminars in Neurology. 32 (04): 454. doi:10.1055/s-0032-1331815 - Pubmed
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