Gonadoblastomas are uncommon sex cord / stromal tumours. They are associated with disorders of sexual development (previously known as "intersex disorders").

The vast majority are found <30 years of age. Most are discovered in the perinatal period. May occur in phenotypic males or females.

  • associated with disorders of sexual development (previously known as "intersex disorders")
  • often found during a workup for an newborn or infant with ambiguous genitalia
  • may be hormonally active and present with precocious puberty or virilization 5

They are associated with chromosomal abnormalities and gonadal dysgenesis.

Gonadoblastomas are considered by some to be a subtype of undifferentiated (or "mixed" sex cord / stromal tumors, although others consider them distinct entities 2.

Other imaging findings of a developmental sex disorder should be present. They are bilateral in 30-50% of cases.

  • imaging findings are not well defined
  • reported as a hyperechoic lesion in the testicle 4, but data is limited

Although a gonadoblastoma itself is benign, if it is not removed, it tends to develop into a germ cell tumour 2.  They are often discovered coexisting with malignancy. If there is a contralateral undescended testicle, it is often removed, as it is considered likely to also harbor a gonadoblastoma 3.

Ultrasound - testicular and scrotal
Share article

Article information

rID: 33487
Synonyms or Alternate Spellings:
  • Gonadoblastomas

Support Radiopaedia and see fewer ads

Updating… Please wait.

Alert accept

Error Unable to process the form. Check for errors and try again.

Alert accept Thank you for updating your details.