Testicular adrenal rests

Radswiki et al.

Testicular adrenal rests are a rare cause of a testicular mass.

Testicular adrenal rests can be known by a variety of terms 2:

  • testicular adrenal rest tumour (TART)
  • testicular adrenal rest tissue
  • testicular tumour of the adrenogenital syndrome
  • testicular adrenal-like tissue

Can be found in the testis and surrounding tissues in 7.5-15% of newborns and ~1.5% of adults.

Usually, adrenal rests are asymptomatic. If these cells are exposed to elevated levels of adrenocorticotropic hormone, they can enlarge to form masses. They can be clinically identified in patients with congenital adrenal hyperplasia and rarely in patients with Cushing syndrome.

Aberrant adrenal rests represent collections of cells that have become trapped within the developing gonad during fetal development. They are usually less than 5 mm.

As with evaluating other testicular pathology, ultrasound is the modality of choice.

The sonographic appearance of adrenal rests is variable, with some series describing predominantly hypoechoic masses and others reporting heterogeneously hyperechoic masses with shadowing. Lesions are typically multiple, bilateral, and eccentrically located, usually within the mediastinum testis.

It is important to suggest this in the differential diagnosis in the appropriate setting as they are benign lesions and unnecessary orchiectomy can be avoided. Appropriate hormone serum bloodwork can help secure the diagnosis.

Treatment with glucocorticoid replacement therapy results in stabilisation or regression of the masses.

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Article information

rID: 11127
System: Urogenital
Section: Pathology
Tag: testes
Synonyms or Alternate Spellings:
  • Testicular adrenal rests
  • Testicular adrenal rest
  • Testicular adrenal rest tumour (TART)
  • Testicular adrenal rest tissue
  • Testicular tumour of the adrenogenital syndrome
  • Testicular adrenal-like tissue

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