Octreotide scintigraphy
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At the time the article was created Yuranga Weerakkody had no recorded disclosures.
View Yuranga Weerakkody's current disclosuresAt the time the article was last revised Yahya Baba had no financial relationships to ineligible companies to disclose.
View Yahya Baba's current disclosures- Octreotide scan
- In-111 Octreoscan
- Octreoscan
Octreotide scintigraphy uses 111In-labeled octreotide, which is a somatostatin analog; it is also known as Octreoscan, a brand name for 111In-labeled pentetreotide. Pentetreotide is a DTPA-conjugated form of octreotide, originally manufactured by Mallinckrodt Nuclear Medicine LLC, which now forms part of Curium.
The radiotracer is characterized by a high affinity of bond with the somatostatin receptor 2 (SST2). It penetrates inside the cell by endocytosis, first held by lysosomes and then transferred to the nucleus 4,5.
It is particularly useful for the assessment of neuroendocrine tumors, and the Krenning Score is used to grade these, most commonly for peptide receptor radionuclide therapy (PRRT) planning.
Examples include:
Certain non-neuroendocrine tumors can also show uptake in an Octreoscan. Examples include:
Also, certain autoimmune or granulomatous diseases (for example sarcoidosis) may occasionally show octreotide uptake by overexpression of somatostatin receptors 6-8.
Quiz questions
References
- 1. Whiteman M, Serafini A, Telischi F, Civantos F, Falcone S. 111In Octreotide Scintigraphy in the Evaluation of Head and Neck Lesions. AJNR Am J Neuroradiol. 1997;18(6):1073-80. PMC8337293 - Pubmed
- 2. Ramage J, Williams R, Buxton-Thomas M. Imaging Secondary Neuroendocrine Tumours of the Liver: Comparison of I123 Metaiodobenzylguanidine (MIBG) and In111-Labelled Octreotide (Octreoscan). QJM. 1996;89(7):539-42. doi:10.1093/qjmed/89.7.539 - Pubmed
- 3. Guitera-Rovel P, Lumbroso J, Gautier-Gougis M et al. Indium-111 Octreotide Scintigraphy of Merkel Cell Carcinomas and Their Metastases. Ann Oncol. 2001;12(6):807-11. doi:10.1023/a:1011142410535 - Pubmed
- 4. Hornick C, Anthony C, Hughey S, Gebhardt B, Espenan G, Woltering E. Progressive Nuclear Translocation of Somatostatin Analogs. J Nucl Med. 2000;41(7):1256-63. - Pubmed
- 5. Janson E, Westlin J, Ohrvall U, Oberg K, Lukinius A. Nuclear Localization of 111In After Intravenous Injection of [111In-DTPA-D-Phe1]-Octreotide in Patients with Neuroendocrine Tumors. J Nucl Med. 2000;41(9):1514-8. - Pubmed
- 6. Dalm V, van Hagen P, Krenning E. The Role of Octreotide Scintigraphy in Rheumatoid Arthritis and Sarcoidosis. Q J Nucl Med. 2003;47(4):270-8. - Pubmed
- 7. van Hagen P, Krenning E, Kwekkeboom D et al. Somatostatin and the Immune and Haematopoetic System; a Review. Eur J Clin Invest. 1994;24(2):91-9. doi:10.1111/j.1365-2362.1994.tb00972.x - Pubmed
- 8. ten Bokum A, Hofland L, van Hagen P. Somatostatin and Somatostatin Receptors in the Immune System: A Review. Eur Cytokine Netw. 2000;11(2):161-76. - Pubmed
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- Pancreatic neuroendocrine tumours
- Carotid body tumor
- Gastrinoma
- Gastrointestinal neuroendocrine tumours
- Phaeochromocytoma
- Incidental thyroid nodule
- Medical abbreviations and acronyms (S)
- Carcinoid tumour
- Lutetium-177 dotatate
- Paragangliomas of the head and neck
- Gallium-68 DOTATATE
- Bronchial carcinoid tumour
- Krenning score of neuroendocrine tumour uptake
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