Atypical adenomatous hyperplasia of the lung
Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Di Muzio B, Tatco V, Atypical adenomatous hyperplasia of the lung. Reference article, Radiopaedia.org (Accessed on 23 Mar 2025) https://doi.org/10.53347/rID-22168
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22168
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Disclosures:
At the time the article was created Yuranga Weerakkody had no recorded disclosures.
View Yuranga Weerakkody's current disclosures
Last revised:
Disclosures:
At the time the article was last revised Yuranga Weerakkody had no recorded disclosures.
View Yuranga Weerakkody's current disclosures
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Systems:
Synonyms:
- Atypical adenomatous hyperplasia
- Atypical adenomatous hyperplasia (AAH)
- Atypical adenomatous hyperplasia (AAH) of the lung
- AAH
- AAH lung
- Atypical adenomatous hyperplasia (lung)
Atypical adenomatous hyperplasia (AAH) of the lung is a putative precursor lesion of adenocarcinoma of the lung. This entity replaces part of a spectrum of the former bronchoalveolar carcinoma (BAC) and falls under the spectrum of pre-invasive lesions of the lungs.
Pathology
Atypical adenomatous hyperplasia lesions are represented by localized small cell proliferation, usually measuring ≤0.5 cm (<5 mm), of mildly to moderately atypical type II pneumocytes and/or Clara cells that line along the alveolar walls, alveolar septae, or respiratory bronchiole 3,5,8. Subgrading of those lesions according to the spectrum of cellularity and atypia is not recommended 8.
Radiographic features
Their radiographic appearances can be somewhat variable but have been commonly described as ground-glass nodules (usually pure ground glass) measuring less than 5 mm 3-5, opposed to adenocarcinomas in situ, which are also pre-invasive lesions, that tend to be larger.
References
- 1. Kayser K, Nwoye JO, Kosjerina Z et-al. Atypical adenomatous hyperplasia of lung: its incidence and analysis of clinical, glycohistochemical and structural features including newly defined growth regulators and vascularization. Lung Cancer. 2004;42 (2): 171-82. Pubmed citation
- 2. Nakahara R, Yokose T, Nagai K et-al. Atypical adenomatous hyperplasia of the lung: a clinicopathological study of 118 cases including cases with multiple atypical adenomatous hyperplasia. Thorax. 2001;56 (4): 302-5. Free text at pubmed - Pubmed citation
- 3. Park CM, Goo JM, Lee HJ et-al. CT findings of atypical adenomatous hyperplasia in the lung. Korean J Radiol. 2006;7 (2): 80-6. Free text at pubmed - Pubmed citation
- 4. Ishikawa H. [Pathologic/high-resolution CT correlation of focal lung lesions 5 mm or less in diameter: detection and identification by multidetector-row CT]. Nihon Igaku Hoshasen Gakkai Zasshi. 2002;62 (8): 415-22. Pubmed citation
- 5. Kawakami S, Sone S, Takashima S et-al. Atypical adenomatous hyperplasia of the lung: correlation between high-resolution CT findings and histopathologic features. Eur Radiol. 2002;11 (5): 811-4. Pubmed citation
- 6. Godoy MC, Naidich DP. Subsolid pulmonary nodules and the spectrum of peripheral adenocarcinomas of the lung: recommended interim guidelines for assessment and management. Radiology. 2009;253 (3): 606-22. Radiology (full text) - doi:10.1148/radiol.2533090179 - Pubmed citation
- 7. Kim HY, Shim YM, Lee KS et-al. Persistent pulmonary nodular ground-glass opacity at thin-section CT: histopathologic comparisons. Radiology. 2007;245 (1): 267-75. Radiology (full text) - doi:10.1148/radiol.2451061682 - Pubmed citation
- 8. Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D. International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. (2011) Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 6 (2): 244-85. doi:10.1097/JTO.0b013e318206a221 - Pubmed
- 9. Nguyen C, Larsen N, Dietz N, Sirineni G, Balters M. Pulmonary Atypical Adenomatous Hyperplasia: Diagnostic and Therapeutic Implications. Cureus. 2019;11(11):e6079. doi:10.7759/cureus.6079 - Pubmed
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