Adenocarcinoma in situ of the lung

Adenocarcinoma in situ (AIS) of the lung refers to a relatively new entity for a pre-invasive lesion in the lung. This entity partly replaces the noninvasive end of the previous term bronchoalveolar carcinoma. Adenocarcinoma in situ is defined as a localised adenocarcinoma of <3 cm that exhibits a lepidic growth pattern, with neoplastic cells along the alveolar structures but without stromal, vascular, or pleural invasion 1.

Radiographic features


While adenocarcinoma in situ is usually seen as a pure ground-glass nodule or a part-solid lung nodule, there can be is an overlap among the imaging features of atypical adenomatous hyperplasia, adenocarcinoma in situ, and invasive adenocarcinoma of the lung 1.

Treatment and prognosis

Adenocarcinoma in situ carries an excellent prognosis, with reported survival rates of 100% following complete tumour resection.

Lung cancer
Share article

Article information

rID: 22176
System: Chest, Oncology
Tag: cases
Synonyms or Alternate Spellings:
  • Adenocarcinoma in situ (AIS) of lung
  • AIS of lung
  • AIS lung
  • AIS
  • Adenocarcinoma in situ (lung)
  • Adenocarcinoma in situ of lung
  • Adenocarcinoma in situ (AIS) of the lung

Support Radiopaedia and see fewer ads

Updating… Please wait.

Alert accept

Error Unable to process the form. Check for errors and try again.

Alert accept Thank you for updating your details.