Fibrotic non-specific interstitial pneumonitis
Last revised by Sebastian Röhrich ◉
on 4 May 2023
Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Röhrich S, Hacking C, et al. Fibrotic non-specific interstitial pneumonitis. Reference article, Radiopaedia.org (Accessed on 11 Mar 2025) https://radiopaedia.org/articles/25762
DOI:
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rID:
25762
Article created:
Disclosures:
At the time the article was created Yuranga Weerakkody had no recorded disclosures.
View Yuranga Weerakkody's current disclosures
Last revised:
4 May 2023,
Sebastian Röhrich ◉
Disclosures:
At the time the article was last revised Sebastian Röhrich had the following disclosures:
- contextflow GmbH, Medical advisor (ongoing)
These were assessed during peer review and were determined to not be relevant to the changes that were made.
View Sebastian Röhrich's current disclosures
Revisions:
8 times, by
6 contributors -
see full revision history and disclosures
Systems:
Synonyms:
- Fibrotic non-specific interstitial pneumonia
- Fibrosing non specific interstitial pneumonia
- Fibrotic NSIP
- Fibrosing NSIP
- Fibrotic non specific interstitial pneumonitis
- Fibrotic non specific interstitial pneumonia
Fibrotic non-specific interstitial pneumonitis is a histological subtype of non-specific interstitial pneumonitis (NSIP). It is considered the more common form 1. This pattern manifests as chronic interstitial inflammation obscured by interstitial fibrosis (with dense collagen), a temporal homogeneous pattern, and occasional focal honeycomb fibrosis 3.
Treatment and prognosis
Corticosteroid can be given but it carries a worse prognosis than the cellular type.
Differential diagnosis
The key imaging differential is a UIP pattern
- according to one study 62% of patients with UIP showed subpleural predominance whereas 55% of patients with fibrotic NSIP exhibited random distribution 4
References
- 1. Kim DS, Collard HR, King TE. Classification and natural history of the idiopathic interstitial pneumonias. Proc Am Thorac Soc. 2006;3 (4): 285-92. doi:10.1513/pats.200601-005TK - Free text at pubmed - Pubmed citation
- 2. Mueller-Mang C, Grosse C, Schmid K et-al. What every radiologist should know about idiopathic interstitial pneumonias. Radiographics. 2007;27 (3): 595-615. Radiographics (full text) - doi:10.1148/rg.273065130 - Pubmed citation
- 3. Wittram C, Mark EJ, McLoud TC. CT-histologic correlation of the ATS/ERS 2002 classification of idiopathic interstitial pneumonias. Radiographics. 2003;23 (5): 1057-71. doi:10.1148/rg.235035702 - Pubmed citation
- 4. Ho Yun Lee, Kyung Soo Lee, Yeon Joo Jeong, Jung Hwa Hwang, Hyo Jin Kim, Man Pyo Chung, Joungho Han. High-Resolution CT Findings in Fibrotic Idiopathic Interstitial Pneumonias With Little Honeycombing: Serial Changes and Prognostic Implications. (2012) American Journal of Roentgenology. 199 (5): 982-9. doi:10.2214/AJR.11.8192 - Pubmed
- 5. Churg A, Müller NL. Cellular vs fibrosing interstitial pneumonias and prognosis: a practical classification of the idiopathic interstitial pneumonias and pathologically/radiologically similar conditions. (2006) Chest. 130 (5): 1566-70. doi:10.1378/chest.130.5.1566 - Pubmed
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