Lung carcinosarcoma

Last revised by David Luong on 12 Jul 2021

Lung carcinosarcomas are uncommon malignant biphasic tumors classified as a subtype of sarcomatoid tumors of the lung

It is rare and thought to account for <1% of all lung cancers. There may be a greater male predilection with tumor generally occurring in heavy smokers with peak occurrence between the 5th to 8th decades of life 1.

It is defined by coexisting histologic elements of carcinomatous (typically squamous cell carcinoma or adenocarcinoma) and sarcomatous components (eg. rhabdomyosarcoma, chondrosarcoma, and osteosarcoma).

  • TP53 mutations are often present 4
  • KRAS mutations are less frequent 4
  • EGFR mutations are very uncommon 4

Overall prognosis is generally considered poor 1. Some authors suggest carcinomatous portion tending to metastasize to regional lymph nodes whereas the sarcomatous part favoring systemic dissemination 2

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