Primary sarcomatoid carcinoma of the lung

Primary sarcomatoid carcinomas of the lung refer to a heterogeneous group of non-small cell lung carcinomas (NSCLC).

They are thought to account for 0.2 to 1% of all lung cancers 1. A sarcomatoid histology may be present in 0.1-0.4% of non-small cell lung cancers 3

They are poorly differentiated non-small cell cancers that contain a sarcoma or sarcoma-like component. They are the most common pulmonary neoplasms that exhibit a composition by spindled or pleomorphic tumour cells. Due to this reason, they may be confused easily with true sarcomas diagnostically unless special immunohistological or ultrastructural analyses are performed.

Specific subgroups that have been classified under sarcomatoid carcinomas of the lungs include 4,6:

While some publications suggest a poorer prognosis with sarcomatoid histology 3 although this fact appears to be debatable according to other publications 1.

If a sarcomatoid histology is revealed following a biopsy for a lung lesion, differentials to consider include 7:

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Article information

rID: 22566
System: Chest
Section: Pathology
Tag: cases
Synonyms or Alternate Spellings:
  • Sarcomatoid carcinoma of the lung
  • Sarcomatoid carcinoma of lungs
  • Sarcomatoid carcinoma of the lungs
  • Pulmonary sarcomatoid carcinoma
  • Sarcomatoid carcinomas of the lungs
  • Sarcomatoid tumours of the lung
  • Sarcomatoid cancer (SARC) of lungs
  • Sarcomatoid tumours of the lungs
  • Primary sarcomatoid tumours of the lungs
  • Sarcomatoid carcinoma of lung

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